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milbemycin oxime

(CAS: 129496-10-2)

Suppliers of milbemycin oxime

Company Name Email Tel Country
Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: ≥ 98.0% Brand: BOC Sciences

Price and Availability: USD398/500mg (In stock) USD498/1g (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/10mg () USD84/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD25/5mg () USD38/10mg () USD113/50mg () USD175/100mg ()

Hangzhou Holypharm Biotech Co., Ltd. [email protected],[email protected] +86 (571) 8717-6852 / +86 18205813359 China

Fax: +86 (571) 8735-7695Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/10mg () USD84/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD112/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/10mg () USD84/50mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD317/200mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD47/10mg () USD125/50mg () USD210/100mg ()

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Background Information of milbemycin oxime

Milbemycin oxime is a veterinary drug from the group of milbemycins, used as a broad spectrum antiparasitic. It is active against worms (anthelmintic), insects (insecticide) and mites (miticide). Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A. Like avermectins, milbemycins are products of fermentation by Streptomyces species. They have a similar mechanism of action, but a longer half-life than the avermectins. Milbemycin oxime is produced by Streptomyces hygroscopicus aureolacrimosus. It opens glutamate sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer.

Solubility of milbemycin oxime

Solubility Sources
DMSO: 35 mg/mL CHEMSCENE, LLC
DMSO: 35 mg/mL MedChemexpress Co., Ltd.

Storage Condition of milbemycin oxime

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Anti-infection
Target Parasite
Research Area Infection
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
milbemycin oxime - Launched
milbemycin oxime - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
2194.76 C126H176N4O28 129496-10-2

Structure Information of milbemycin oxime

Smiles O=C1[[email protected]@]([[email protected]@]2(O)[[email protected]@](OC/C2=CC=C[[email protected]](C)C/C(C)=C/C[[email protected]@]3([H])O[[email protected]]4(O[[email protected]](CC)[[email protected]@H](C)CC4)C[[email protected]@](C3)([H])O1)([H])/C5=N/O)(C=C5C)[H].O=C6[[email protected]@]([[email protected]@]7(O)[[email protected]@](/C8=NO)(OC/C7=CC=C[[email protected]](C)C/C(C)=C/C[[email protected]@]9([H])O[[email protected]@](O[[email protected]@H]%10CC)(CC[[email protected]@H]%10C)C[[email protected]@](C9)([H])O6)[H])(C=C8C)[H].O=C%11[[email protected]@](C=C/%12C)([H])[[email protected]@]%13(O)[[email protected]](C%12=NO)([H])OC/C%13=CC=C[[email protected]](C)C/C(C)=C/C[[email protected]@]%14([H])O[[email protected]@](O[[email protected]@H]%15C)(CC[[email protected]@H]%15C)C[[email protected]@](C%14)([H])O%11.O=C%16[[email protected]@](C=C/%17C)([H])[[email protected]@]%18(O)[[email protected]](C%17=N/O)([H])OC/C%18=CC=C[[email protected]](C)C/C(C)=C/C[[email protected]@]%19([H])O[[email protected]@](O[[email protected]@H]%20C)(CC[[email protected]@H]%20C)C[[email protected]@](C%19)([H])O%16
InChI InChI=1S/2C32H45NO7.2C31H43NO7/c2*1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;2*1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h2*7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;2*6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b8-7+,20-10+,23-9+,33-28+;8-7+,20-10+,23-9+,33-28-;7-6+,19-9+,23-8+,32-27+;7-6+,19-9+,23-8+,32-27-/t2*19-,21-,24+,25-,26-,27+,29+,31+,32+;2*18-,20-,22+,24+,25-,26-,28+,30-,31+/m0000/s1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL;In vitro:Ethanol,100 mg/mL;In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

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