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INT-747

(CAS: 459789-99-2)

Suppliers of INT-747

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

China Yangtze Pchem Co., Ltd. [email protected] +86 (717) 630-7579 China

Fax: +86 (717) 630-7522Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: HNMR HNMR HNMR MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: Inquiry Brand:

Price and Availability: USD25/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand: Selleck

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD81/10mg () USD148/25mg () USD218/50mg ()

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Background Information of INT-747

INT-747 is a potent and selective FXR agonist (EC50=99 nM) endowed with anticholestatic activity.

Solubility of INT-747

Solubility Sources
50 mM in ethanol; 75 mM in DMSO CHEMSCENE, LLC
50 mM in ethanol; 75 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of INT-747

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target FXR
Research Area Others
Indications Liver Cirrhosis, Biliary

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
INT-747 Intercept Pharmaceuticals Liver Cirrhosis, Biliary 2007/10/27 Phase 2 Clinical
INT-747 Intercept Pharmaceuticals Liver Cirrhosis, Biliary 2007/12/07 Phase 2 Clinical
INT-747 - Phase 3 Clinical
INT-747 - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
420.6252 C26H44O4 459789-99-2 Obeticholic acid;6-ECDCA;6-Ethylchenodeoxycholic acid

Structure Information of INT-747

Smiles C[[email protected]@]([[email protected]]1([H])[[email protected]@H](CC)[[email protected]]2O)(CC[[email protected]@H](O)C1)[[email protected]]3([H])[[email protected]]2([H])[[email protected]@](CC[[email protected]]4([H])[[email protected]](C)CCC(O)=O)([H])[[email protected]]4(C)CC3
InChI InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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