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IWR-1

(CAS: 1127442-82-3)

Suppliers of IWR-1

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Price and Availability: USD90/10mg (In stock)

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD56/10mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD70/10mgmg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Price and Availability: USD198/25mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD92/10mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD149/5mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD54/5mg ()

Lancrix Chemicals. [email protected] 86 21 50817262 China

Fax: 86 21 57712035Purity: Brand:

Price and Availability: USD50/5mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD92/10mg ()
Quality Control & MSDS Files: HNMR LCMS LCMS MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD110/10mg (In stock) USD250/25mg (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD92/10mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Price and Availability: USD72/5mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .992 Brand: TargetMol

Price and Availability: USD42/2mg () USD69/5mg () USD115/10mg () USD168/25mg () USD242/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD129/10mg ()

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Background Information of IWR-1

IWR-1(IWR-1-endo) is a novel small molecule Wnt signaling by stabilizing the Axin destruction complex with an EC50 of 0.2 uM. IC50 value: 0.2 uM (EC50) [1] Target: Wnt signaling During NSPC differentiation, MIF increased the activity of β-galactosidase that responds to Wnt/β-catenin signaling.

Solubility of IWR-1

Solubility Sources
DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 30 mg/mL (73.27 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of IWR-1

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Stem Cell/Wnt
Target Wnt
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
IWR-1 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
409.44 C25H19N3O3 1127442-82-3 endo-IWR 1;IWR-1-endo;IWR1;IWR 1; 4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(quinolin-8-yl)benzamide

Structure Information of IWR-1

Smiles O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([[email protected]]4([H])[[email protected]](C5)([H])C=C[[email protected]]5([H])[[email protected]]64[H])=O)C6=O)C=C3
InChI InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.425±0.06 g/cm3 (20 ºC 760 Torr), Calc.* Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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