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MMAF (Hydrochloride)

(CAS: 1415246-68-2)

Suppliers of MMAF (Hydrochloride)

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD180/2mg () USD336/5mg ()

Chendu Sinostandards Bio-Tech Co., Ltd [email protected] 0086-28-83243029 China

Fax: 0086-28-8324 0018Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD180/2mg () USD336/5mg ()
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD180/2mg () USD336/5mg ()

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Background Information of MMAF (Hydrochloride)

Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin. IC50 value: Target: tubulin; ADCs cytotoxin MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE).

Solubility of MMAF (Hydrochloride)

Solubility Sources

Storage Condition of MMAF (Hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
Target Microtubule/Tubulin ADC Cytotoxin
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MMAF (Hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
768.42 C39H66ClN5O8 1415246-68-2 Monomethylauristatin F Hydrochloride; (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid hydrochloride

Structure Information of MMAF (Hydrochloride)

Smiles CC(C)[[email protected]](NC)C(N[[email protected]](C(N([[email protected]@H]([[email protected]@H](C)CC)[[email protected]](OC)CC(N1CCC[[email protected]@]1([H])[[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C(O)=O)CC2=CC=CC=C2)=O)=O)C)=O)C(C)C)=O.Cl
InChI InChI=1S/C39H65N5O8.ClH/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27;/h13-15,17-18,23-26,28-30,32-35,40H,12,16,19-22H2,1-11H3,(H,41,46)(H,42,47)(H,49,50);1H/t25-,26+,28?,29-,30+,32-,33-,34-,35+;/m0./s1

Related Products

Other Form Products of MMAF (Hydrochloride)

Name CAS Formula Suppliers
MMAF 745017-94-1 C39H65N5O8 9
MMAF (sodium) 1799706-65-2 C39H64N5NaO8 1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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