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Palbociclib (isethionate)

(CAS: 827022-33-3)

Suppliers of Palbociclib (isethionate)

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

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Price and Availability: USD15/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

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Price and Availability: USD120/10mg (In stock)

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD103/10mg (In stock)

Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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Price and Availability: USD162/10mg (In Stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD188/250mg (In stock)

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD115/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/5mg () USD84/10mg ()

ChemieTek [email protected] +1 (317) 598-0828 USA

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Price and Availability: USD100/10mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: > 99% Brand:

Price and Availability: USD47/10mg (In stock) USD64/25mg (In stock) USD87/50mg (In stock) USD139/100mg (In stock) USD235/200mg (In stock) USD484/500mg (In stock) USD792/1g (In stock) USD1384/2g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: NP-HPLC HNMR LCMS MSDS

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD220/1mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD147/10mg (In stock) USD270/25mg (In stock) USD370/50mg (In stock) USD1070/200mg (In stock)
Quality Control & MSDS Files: HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Shanghai XingMo Biotechnology Co., Ltd. [email protected] 13524779951 CHINA

Fax: Purity: > 98% Brand: X-MoBio

Price and Availability: USD600/1g (In stock)

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Price and Availability: USD86/5mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD125/10mg () USD198/25mg () USD352/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD215/10mg ()

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Background Information of Palbociclib (isethionate)

Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

Solubility of Palbociclib (isethionate)

Solubility Sources
DMSO <1 mg/mL (<1 mM) ; Water 100 mg/mL (174 mM) ; Ethanol <1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Palbociclib (isethionate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[NP-HPLC] [HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Metastatic breast cancer Breast tumor Gastrointestinal stromal tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Palbociclib (isethionate) Pfizer Inc Metastatic breast cancer 2013/9/30 2017/1/31 Phase 3 Clinical
Palbociclib (isethionate) German Breast Group Breast tumor 2013/10/31 2021/11/30 Phase 3 Clinical
Palbociclib (isethionate) Institut Bergonie Gastrointestinal stromal tumor 2013/8/31 2015/8/31 Phase 2 Clinical
Palbociclib (isethionate) Washington University in St Louis Breast tumor 2013/6/30 2015/8/31 Phase 2 Clinical
Palbociclib (isethionate) Pfizer Inc Metastatic breast cancer 2013/2/28 2015/3/31 Phase 3 Clinical
Palbociclib (isethionate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
573.66 C26H35N7O6S 827022-33-3 PD0332991 isethionate;PD-0332991 isethionate;PD 0332991 isethionate; 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate

Structure Information of Palbociclib (isethionate)

Smiles CC(C1=C(N2C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C1)=C(C(C)=O)C2=O.OCCS(O)(=O)=O
InChI InChI=1S/C24H29N7O2.C2H6O4S/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;3-1-2-7(4,5)6/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);3H,1-2H2,(H,4,5,6)

Related Products

Other Form Products of Palbociclib (isethionate)

Name CAS Formula Suppliers
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 16
Palbociclib 571190-30-2 C24H29N7O2 12

Recommended Products in Same Target

Name CAS Formula Suppliers
LY2857785 1619903-54-6 C26H36N6O 6
THZ2 1604810-84-5 C31H28ClN7O2 4
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 4
ML167 1285702-20-6 C19H17N3O3 7
AMG 925 1401033-86-0 C26H29N7O2 12
LDC000067 1073485-20-7 C18H18N4O3S 9
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 6
LEE011 (succinate) 1374639-75-4 C27H36N8O5 6
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 5
LEE011 1211441-98-3 C23H30N8O 17
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 5
Wogonin 632-85-9 C16H12O5 21
1-NM-PP1 221244-14-0 C20H21N5 14
WHI-P180 211555-08-7 C16H15N3O3 7
THZ1 1604810-83-4 C31H28ClN7O2 9
Senexin A 1366002-50-7 C17H14N4 4
CDK4-IN-1 1256963-02-6 C22H29ClN8 8
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 16
Purvalanol B 212844-54-7 C20H25ClN6O3 12
NU6102 444722-95-6 C18H22N6O3S 1

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Name CAS Formula Suppliers
Regorafenib 755037-03-7 C21H15ClF4N4O3 16
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Toremifene 89778-26-7 C26H28ClNO 6
Toremifene (Citrate) 89778-27-8 C32H36ClNO8 8
MK-0752 471905-41-6 C21H21ClF2O4S 9
Cyclophosphamide 50-18-0 C7H15Cl2N2O2P 13
Linsitinib 867160-71-2 C26H23N5O 12
Fenretinide 65646-68-6 C26H33NO2 20
Retaspimycin 857402-23-4 C31H45N3O8 5
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 4
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 10
Litronesib 910634-41-2 C23H37N5O4S2 6
Veliparib 912444-00-9 C13H16N4O 11
Veliparib (dihydrochloride) 912445-05-7 C13H18Cl2N4O 8
AT13387 912999-49-6 C24H31N3O3 13
Ganetespib 888216-25-9 C20H20N4O3 13
Ixabepilone 219989-84-1 C27H42N2O5S 11
Imatinib (Mesylate) 220127-57-1 C30H35N7O4S 21
Reparixin 266359-83-5 C14H21NO3S 9
Reparixin (L-lysine salt) 266359-93-7 C20H35N3O5S 7

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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