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GW311616 (hydrochloride)

(CAS: 197890-44-1)

Suppliers of GW311616 (hydrochloride)

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Adipogen Corporation [email protected] (858) 457-8383 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD332/5mg (In stock)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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Price and Availability: USD162/2mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD420/5mg () USD600/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD420/5mg () USD600/10mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

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Background Information of GW311616 (hydrochloride)

GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM. IC50 value: 22 nM [1] Target: neutrophil elastase The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator).

Solubility of GW311616 (hydrochloride)

Solubility Sources

Storage Condition of GW311616 (hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Elastase
Research Area Inflammation/Immunology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
GW311616 (hydrochloride) - Not Found
GW311616 (hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
433.99 C19H32ClN3O4S 197890-44-1 GW-311616 hydrochloride;GW 311616 hydrochloride;GW311616A; (3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride

Structure Information of GW311616 (hydrochloride)

Smiles O=C1[[email protected]@H](C(C)C)[[email protected]@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[[email protected]]3([H])N1S(=O)(C)=O.[H]Cl
InChI InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1

Related Products

Other Form Products of GW311616 (hydrochloride)

Name CAS Formula Suppliers
GW311616 198062-54-3 C19H31N3O4S 9

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:>21.7mg/mL in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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