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GW311616 (hydrochloride)

(CAS: 197890-44-1)

Suppliers of GW311616 (hydrochloride)

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD332/5mg (In stock)

Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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Price and Availability: USD162/2mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

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Background Information of GW311616 (hydrochloride)

GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM. IC50 value: 22 nM [1] Target: neutrophil elastase The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator).

Solubility of GW311616 (hydrochloride)

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Storage Condition of GW311616 (hydrochloride)

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MSDS Information

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Quality Control and Spectral Data

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Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Elastase
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
GW311616 (hydrochloride) - Not Found
GW311616 (hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
433.99 C19H32ClN3O4S 197890-44-1 GW-311616 hydrochloride;GW 311616 hydrochloride;GW311616A; (3S,3aS,6aR)-3-isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride

Structure Information of GW311616 (hydrochloride)

Smiles O=C1[[email protected]@H](C(C)C)[[email protected]@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[[email protected]]3([H])N1S(=O)(C)=O.[H]Cl
InChI InChI=1S/C19H31N3O4S.ClH/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H/b8-7+;/t15-,17+,18-;/m1./s1

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Other Form Products of GW311616 (hydrochloride)

Name CAS Formula Suppliers
GW311616 198062-54-3 C19H31N3O4S 6

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Chemical and Physical Properties

Appearance: Melting point:
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