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Melphalan

(CAS: 148-82-3)

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: HNMR LCMS MSDS

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Background Information of Melphalan

Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. IC50 value: Target: DNA alkylator The agent was first investigated as a possible drug for use in melanoma.

Solubility of Melphalan

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Melphalan

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target DNA Alkylator/Crosslinker
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Melphalan - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
305.2 C13H18Cl2N2O2 148-82-3 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; L-Phenylalanine mustard; L-PAM; 2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid

Structure Information of Melphalan

Smiles O=C(O)C(N)CC1=CC=C(N(CCCl)CCCl)C=C1
InChI InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)

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Safety Data of Melphalan

Hazard Symbols:T+ Risk Statements:R45;R46;R26/27/28;R63 Safety Statements:S53;S22;S36/37/39;S45
Transport Information:UN 2811 HS Code: RTECS:AY3675000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:~180 °C
Boiling point: Flash Point:
Water Solubility: <0.1 g/100 mL at 22 ºC Solubility:>6.9mg/mL in DMSO
Density: Merck:13,5850
BRN: Refractive Index:
Vapour: EINECS:205-726-3
Optical Rotation: alpha:

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