CB-839
(CAS: 1439399-58-2)
Background Information of CB-839
CB-839 is a potent and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC), and with IC50s of 23 nM and 28 nM in kidney and brain, respectively.
Storage Condition of CB-839
Quality Control and Spectral Data
Mechanism and Indications
Clinical Information
Product Name |
Sponsor & Collaborators |
Indications |
Start Date |
End Date |
Phase |
CB-839
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- |
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No Development Reported |
CB-839
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- |
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Phase 2 |
Chemical Information
M.Wt |
Formula |
CAS No. |
Synonyms |
571.57 |
C26H24F3N7O3S |
1439399-58-2 |
2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide |
Structure Information of CB-839
Smiles |
O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4 |
InChI |
InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38) |
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Chemical and Physical Properties
Appearance:White to off-white Solid |
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Solubility:In vitro:DMSO,100 mg/mLwarmed(174.95 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+corn oilFor best results, use promptly afte |
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