T-5224
(CAS: 530141-72-1)
Background Information of T-5224
T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice.
IC50 value:
Target: c-Fos/AP1 inhibitor
in vitro: T-5224 was converted to its acyl O-glucuronide (G2) by UGT1A1 and UGT1A3 and to its hydroxyl O-glucuronide (G3) by several UGTs, but it was not metabolized by the P450s [2].
in vivo: Administration of T-5224 (300 mg kg(-1), p.o.) after intraperitoneal injection of LPS imparted appreciable protection against acute elevations in serum levels of TNFα, HMGB1, ALT/AST as well as in liver tissue levels of MIP-1α and MCP-1, and reduced the lethality (27 %) [1].
Storage Condition of T-5224
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Quality Control and Spectral Data
Mechanism and Indications
Clinical Information
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T-5224
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T-5224
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No Development Reported |
Chemical Information
| M.Wt |
Formula |
CAS No. |
Synonyms |
| 517.53 |
C29H27NO8 |
530141-72-1 |
T5224;T 5224; 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxybenzo[d]isoxazol-6-yl)methoxy)phenyl)propanoic acid |
Structure Information of T-5224
| Smiles |
OC1=NOC2=CC(COC3=C(CCC(O)=O)C=C(C(C4=C(O)C=C(OC5CCCC5)C=C4)=O)C=C3)=CC=C21 |
| InChI |
InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33) |
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Chemical and Physical Properties
| Appearance:Light yellow to yellow Solid |
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