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(CAS: 353519-63-8)

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: HNMR LCMS MSDS

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Background Information of HLM006474

HLM006474 is a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system; interferes with E2F activity. IC50 value: 29.8 μM(EC50 in vivo) Target: E2F inhibitor in vivo: HLM006474 is not specific to E2F4 and appears to inhibit binding by all E2F complexes.

Solubility of HLM006474

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of HLM006474

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR Cell Cycle/DNA Damage
Target ATM/ATR
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
HLM006474 - Not Found
HLM006474 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
399.48 C25H25N3O2 353519-63-8 HLM 006474;HLM-006474; 7-((4-ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol

Structure Information of HLM006474

Smiles OC(C1=NC(C)=CC=C1C=C2)=C2C(NC3=NC=CC=C3)C(C=C4C)=CC=C4OCC
InChI InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)

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ATM-IN-2 1941214-06-7 C23H23FN6O2 1
ATM-IN-3 C24H25FN6O2 0
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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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