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Tyrphostin A1

(CAS: 2826-26-8)

Suppliers of Tyrphostin A1

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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EMD Millipore USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: LCMS HNMR

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

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Tianjin Heowns Biochemical Technology Co., Ltd. [email protected] (022) 83717335, 83717309, 8371735 China

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Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Background Information of Tyrphostin A1

Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value: Target: IL-12 production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM.

Solubility of Tyrphostin A1

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Tyrphostin A1

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Immunology/Inflammation
Target Interleukin Related
Research Area Inflammation/Immunology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tyrphostin A1 - Not Found
Tyrphostin A1 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
184.19 C11H8N2O 2826-26-8 Tyrphostin 1;AG9; 2-(4-methoxybenzylidene)malononitrile

Structure Information of Tyrphostin A1

Smiles N#C/C(C#N)=CC1=CC=C(OC)C=C1
InChI InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:113-116 °C(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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