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Talabostat (mesylate)

(CAS: 150080-09-4)

Suppliers of Talabostat (mesylate)

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD242/10mg (In stock)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 98% Brand: BOC Sciences

Price and Availability: USD290/20mg (In stock)

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD132/5mg () USD192/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD132/5mg () USD192/10mg ()
Quality Control & MSDS Files: HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD132/5mg () USD192/10mg ()

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Background Information of Talabostat (mesylate)

Talabostat mesilate(PT-100; Val-boroPro) is an orally active, specific inhibitor of dipeptidyl peptidases(IC50=1 nM for DPP4), including tumor-associated fibroblast activation protein. IC50 value: 1 nM [1] Tareget: DPP4 By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity.

Solubility of Talabostat (mesylate)

Solubility Sources

Storage Condition of Talabostat (mesylate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Dipeptidyl Peptidase
Research Area Cancer
Indications Kidney Cancer Brain and Central Nervous System Tumors Pancreatic Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Talabostat (mesylate) University of Nebraska Kidney Cancer 2007/6/20 2013/5/01 Withdrawn
Talabostat (mesylate) National Institutes of Health Clinical Center Brain and Central Nervous System Tumors 2006/3/15 Phase 1 Clinical
Talabostat (mesylate) Point Therapeutics Pancreatic Cancer 2005/6/28 2007/6/01 Phase 2 Clinical
Talabostat (mesylate) - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
310.18 C10H23BN2O6S 150080-09-4 [(2R)-1-[(2S)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid mesylate; methanesulfonic acid compound with ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1)

Structure Information of Talabostat (mesylate)

Smiles CC(C)[[email protected]@H](C(N1[[email protected]@H](CCC1)B(O)O)=O)N.CS(O)(=O)=O
InChI InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1

Related Products

Other Form Products of Talabostat (mesylate)

Name CAS Formula Suppliers
Talabostat 149682-77-9 C9H19BN2O3 7

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:>11.45mg/mL in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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