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AGN 195183

(CAS: 191469-29-1)

Suppliers of AGN 195183

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD332/5mg ()

BOC Sciences [email protected] 1-631-504-6093

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD350/5mg (In stock) USD500/10mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD350/5mg (Get quote) USD500/10mg (Get quote)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Background Information of AGN 195183

AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ. IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Target: RARα agonist Compound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580.

Solubility of AGN 195183

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of AGN 195183

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] [HNMR] [MS] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AGN 195183 - Phase 2 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
387.42 C22H23F2NO3 191469-29-1 AGN195183;AGN-195183; 2,6-difluoro-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid

Structure Information of AGN 195183

Smiles O=C(O)C1=C(F)C=C(NC(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
InChI InChI=1S/C22H23F2NO3/c1-21(2)7-8-22(3,4)15-9-12(5-6-14(15)21)19(26)25-13-10-16(23)18(20(27)28)17(24)11-13/h5-6,9-11H,7-8H2,1-4H3,(H,25,26)(H,27,28)

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Chemical and Physical Properties

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