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(CAS: 1191911-26-8)

Suppliers of CZC-25146

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Quality Control & MSDS Files: LCMS HNMR

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Background Information of CZC-25146

CZC-25146 is a potent, selective and metabolically stable LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2 respectively. IC50 value: 4.76 nM/6.87 nM(wild type/G2019S LRRK2) [1] Target: LRRK2 CZC-25146displayed a very clean profile, it inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2 and PIP4K2C) with high potency, none of which have been classified as predictors of genotoxicity or hematopoietic toxicity.

Solubility of CZC-25146

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of CZC-25146

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Autophagy
Target LRRK2
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
CZC-25146 - Not Found
CZC-25146 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
488.54 C22H25FN6O4S 1191911-26-8 CZC25146;CZC 25146; N-(2-((5-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide

Structure Information of CZC-25146

InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)

Related Products

Other Form Products of CZC-25146

Name CAS Formula Suppliers
CZC-25146 (hydrochloride) 1330003-04-7 C22H25FN6O4S 9

Recommended Products in Same Target

Name CAS Formula Suppliers
GNE-9605 1536200-31-3 C17H20ClF4N7O 15
CZC-25146 (hydrochloride) 1330003-04-7 C22H25FN6O4S 9
GNE0877 1374828-69-9 C14H16F3N7 16
GNE-7915 1351761-44-8 C19H21F4N5O3 19
HG-10-102-01 1351758-81-0 C17H20ClN5O3 11
GSK2578215A 1285515-21-0 C24H18FN3O2 20
LRRK2-IN-1 1234480-84-2 C31H38N8O3 19
JH-II-127 1700693-08-8 C19H21ClN6O3 14
CZC-54252 1191911-27-9 C22H25ClN6O4S 13
PF-06447475 1527473-33-1 C17H15N5O 15
MLi-2 1627091-47-7 C21H25N5O2 6
PFE-360 1527475-61-1 C16H16N6O 0
Lu AF58786 1632368-13-8 C19H16N6 0
GNE-7915 (tosylate) C26H29F4N5O6S 0
CZC-25146 (hydrochloride) 1330003-04-7 C22H26ClFN6O4S 6
GNE-09605 1536200-31-3 C17H20ClF4N7O 0

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Chemical and Physical Properties

Appearance:pale purple to purple Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO:48.85mg/mL;100mM;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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