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Berberine (chloride)

(CAS: 633-65-8)

Suppliers of Berberine (chloride)

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

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Adipogen Corporation [email protected] (858) 457-8383 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD66/100mg () USD240/500mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD66/100mg () USD240/500mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD66/100mg () USD240/500mg ()

Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

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Price and Availability: USD30/5g ()

Wuhan Yuancheng Technology Development Co., Ltd [email protected] 027-68886678 CHINA

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Xi'an Saina Biological Technology Co., Ltd. [email protected] +86 (29) 8247-6857 ex 808 China

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Background Information of Berberine (chloride)

An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53.

Solubility of Berberine (chloride)

Solubility Sources

Storage Condition of Berberine (chloride)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Autophagy Stem Cell/Wnt
Target β-catenin Autophagy Wnt
Research Area Cancer
Indications Nonalcoholic Fatty Liver Disease Diabetes Mellitus, Type 2 Metabolic Syndrome

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Berberine (chloride) Xin Gao, Fudan University Nonalcoholic Fatty Liver Disease 2008/3/03 2012/6/01 Phase 2 Clinical
Berberine (chloride) Shanghai Jiao Tong University School of Medicine Diabetes Mellitus, Type 2 2007/4/16 2007/4/01 Phase 3 Clinical
Berberine (chloride) Shanghai Jiao Tong University School of Medicine Metabolic Syndrome 2007/4/16 2007/4/01 Phase 3 Clinical
Berberine (chloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
371.8142 C20H18ClNO4 633-65-8 BBR;Umbellatine

Structure Information of Berberine (chloride)

Smiles COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[Cl-]
InChI InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

Related Products

Other Form Products of Berberine (chloride)

Name CAS Formula Suppliers
Berberine 2086-83-1 C20H18NO4+ 6
Berberine (hydrochloride) 633-65-8 25

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Berberine (hydrochloride) 633-65-8 25
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KY1220 292168-79-7 C14H10N4O3S 5
Oleandrin 465-16-7 C32H48O9 3
Salinomycin 53003-10-4 C42H70O11 4
Berberine (chloride hydrate) 141433-60-5 C20H20ClNO5 6
C-82 1422253-37-9 C33H34N6O4 1

Recommended Products in the Same Indication

Name CAS Formula Suppliers
Berberine (hydrochloride) 633-65-8 25
APD597 897732-93-3 C21H29N5O6S 12
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Gosogliptin 869490-23-3 C17H24F2N6O 9

Safety Data of Berberine (chloride)

Hazard Symbols:Xn Risk Statements:20/21/22 Safety Statements:
Transport Information: HS Code: RTECS:DR9866400
WGK Germany:2

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:204-206 °C (dec.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro: DMSO,40 mg/mL(107.58 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):4% DMSO+30% PEG 300+ddH2OFor best results, use promptly a
Density: Merck:14,1154
BRN:3836585 Refractive Index:
Vapour: EINECS:211-195-9
Optical Rotation: alpha:

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