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VU 0240551

(CAS: 893990-34-6)

Suppliers of VU 0240551

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AOBIOUS INC [email protected] (508) 306-0937 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD114/5mg () USD168/10mg ()
Quality Control & MSDS Files: LCMS HNMR

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of VU 0240551

VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). IC50 value: 560 nM [1] Target: K-Cl cotransporter(KCC2) VU 0240551 exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl.

Solubility of VU 0240551

Solubility Sources
Soluble to 100 mM in DMSO and to 25 mM in ethanol MedChemexpress Co., Ltd.

Storage Condition of VU 0240551

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target Potassium Channel
Research Area Others
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
VU 0240551 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
342.44 C16H14N4OS2 893990-34-6 VU0240551;VU-0240551; N-(4-methylthiazol-2-yl)-2-((6-phenylpyridazin-3-yl)thio)acetamide

Structure Information of VU 0240551

Smiles O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3
InChI InChI=1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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