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Aurothioglucose

(CAS: 12192-57-3)

Suppliers of Aurothioglucose

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Hubei Xiangyun Group [email protected] +86 (713) 654-8630 / +86 15327758267 China

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Hubei Xiangyun Group [email protected] 0713-6542366 CHINA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

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Background Information of Aurothioglucose

Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells. IC50 value: Target: TrxR1 in vitro: Trx1 redox state and ROS generation were measured in cells exposed to the TrxR1 inhibitors aurothioglucose (ATG) and monomethylarsonous acid (MMA(III)) and in cells depleted of TrxR1 activity by siRNA knock down [1]. in vivo: Adult mice received a single intratracheal dose of 0.375 μg/g lipopolysaccharide (LPS) 12 h before a single intraperitoneal injection of 25 mg/kg ATG.

Solubility of Aurothioglucose

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Aurothioglucose

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Others
Target Others
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Aurothioglucose - No Development Reported
Aurothioglucose - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
392.18 C6H11AuO5S 12192-57-3 Gold thioglucose; (1-D-Glucosylthio)gold; (1-Thio-D-glucopyranosato)gold; (alpha-D-Glucopyranosylthio)gold; (((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)thio)gold

Structure Information of Aurothioglucose

Smiles O[[email protected]@H]1[[email protected]@H](CO)OC(S[Au])[[email protected]](O)[[email protected]]1O
InChI InChI=1S/C6H12O5S.Au/c7-1-2-3(8)4(9)5(10)6(12)11-2;/h2-10,12H,1H2;/q;+1/p-1/t2-,3-,4+,5-,6?;/m1./s1

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Safety Data of Aurothioglucose

Hazard Symbols:Xn Risk Statements:42/43 Safety Statements:22-36/37-45
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:13,887
BRN: Refractive Index:
Vapour: EINECS:235-365-7
Optical Rotation: alpha: ymsGold thioglucose; (1-D-Glucosylthio)gold; (1-Thio-D-glucopyranosato)gold; (alpha-D-Glucopyranosylthio)gold

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