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(R)-(-)-Rolipram

(CAS: 85416-75-7)

Suppliers of (R)-(-)-Rolipram

Company Name Email Tel Country
Abcam [email protected] (888) 77-ABCAM (22226) USA

Fax: (877) 774-8286 / (617) 577-4201Purity: Brand:

Price and Availability: USD639/50mg ()

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

Price and Availability: USD980/1g ()

Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

Fax: +31 50 3600390Purity: Brand:

Price and Availability: USD132/10mg (In Stock) USD492/50mg (In Stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD110/10mg () USD390/50mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD110/10mg () USD390/50mg ()
Quality Control & MSDS Files: LCMS HNMR NP-HPLC MSDS

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD158/5mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD110/10mg () USD390/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD189/10mg ()

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

Fax: 03-3668-0520Purity: Brand:

Price and Availability: USD138/10mg ()

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Background Information of (R)-(-)-Rolipram

(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. IC50 value: Target: PDE4 in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 +/- 0.09 microM) in enhancing isoprenaline (10 microM)-stimulated cyclic AMP accumulation.

Solubility of (R)-(-)-Rolipram

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of (R)-(-)-Rolipram

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Phosphodiesterase (PDE)
Research Area Neurological Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
(R)-(-)-Rolipram - No Development Reported
(R)-(-)-Rolipram - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
275.34 C16H21NO3 85416-75-7 (R)-Rolipram;(-)-Rolipram; (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Structure Information of (R)-(-)-Rolipram

Smiles O=C1NC[[email protected]@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1

Related Products

Other Form Products of (R)-(-)-Rolipram

Name CAS Formula Suppliers
Rolipram 61413-54-5 C16H21NO3 19

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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