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Saxagliptin (hydrate)

(CAS: 945667-22-1)

Suppliers of Saxagliptin (hydrate)

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Price and Availability: USD404/1g (In Stock)

BOC Sciences [email protected] 1-631-504-6093

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Beijing Huikang Boyuan Chemical Tech Co., Ltd. [email protected],[email protected] +86 (10) 6886-2197 / 6886-7502 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD108/10mg () USD288/50mg ()

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

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Price and Availability: USD400/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD108/10mg () USD288/50mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD108/10mg () USD288/50mg ()

Shanghai Pansopharm Technology Co., Ltd. [email protected] +86 (21) 2096-2833 / +86 15618308650 China

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Taizhou Apler Chemical Industry Co., Ltd. [email protected] +86 13777640567 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD39/2mg () USD87/10mg () USD317/50mg ()

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Background Information of Saxagliptin (hydrate)

Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. IC50 value: 26 nM [1] Target: DPP4 in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM.

Solubility of Saxagliptin (hydrate)

Solubility Sources

Storage Condition of Saxagliptin (hydrate)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Saxagliptin (hydrate) - Launched
Saxagliptin (hydrate) NHS Tayside; University of Dundee Insulin dependent diabetes 2012/9/30 2014/4/30 Phase 4 Clinical
Saxagliptin (hydrate) Shanghai Jiao Tong University Non-insulin dependent diabetes 2012/10/31 2014/5/01 Phase 4 Clinical
Saxagliptin (hydrate) Duke University Heart disease 2013/3/31 2014/5/31 Phase 4 Clinical
Saxagliptin (hydrate) Shanghai Jiao Tong University Non-insulin dependent diabetes 2012/7/31 2013/3/31 Phase 4 Clinical
Saxagliptin (hydrate) AstraZeneca plc Non-insulin dependent diabetes 2012/11/30 2014/3/31 Phase 4 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
333.43 C18H27N3O3 945667-22-1 BMS-477118 hydrate;Onglyza hydrate;BMS 477118 hydrate;BMS477118 hydrate; (1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate

Structure Information of Saxagliptin (hydrate)

Smiles N[[email protected]@H]([[email protected]@]1(C[[email protected]]2C3)C[[email protected]@]3(O)C[[email protected]](C2)C1)C(N([[email protected]@H](C4)C#N)[[email protected]@H]5[[email protected]]4C5)=O.O
InChI InChI=1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10-,11+,12-,13+,14+,15-,17+,18-;/m1./s1

Related Products

Other Form Products of Saxagliptin (hydrate)

Name CAS Formula Suppliers
(1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride 709031-78-7 C18H26ClN3O2 13
Saxagliptin 361442-04-8 C18H25N3O2 22

Recommended Products in Same Target

Name CAS Formula Suppliers
Talabostat (mesylate) 150080-09-4 C10H23BN2O6S 10
Omarigliptin 1226781-44-7 C17H20F2N4O3S 17
Sitagliptin (phosphate) 654671-78-0 C16H18F6N5O5P 11
Sitagliptin 486460-32-6 C16H15F6N5O 19
Teneligliptin (hydrobromide) 906093-29-6 C44H65Br5N12O2S2 13
Trelagliptin (succinate) 1029877-94-8 C22H26FN5O6 14
Trelagliptin 865759-25-7 C18H20FN5O2 18
Anagliptin 739366-20-2 C19H25N7O2 10
Teneligliptin 760937-92-6 C22H30N6OS 12
Vildagliptin 274901-16-5 C17H25N3O2 27
Talabostat 149682-77-9 C9H19BN2O3 7
Gosogliptin 869490-23-3 C17H24F2N6O 9
Dutogliptin 852329-66-9 C10H20BN3O3 6
Alogliptin 850649-61-5 C18H21N5O2 14
Alogliptin (Benzoate) 850649-62-6 C25H27N5O4 21
Saxagliptin 361442-04-8 C18H25N3O2 22
Linagliptin 668270-12-0 C25H28N8O2 23
Sitagliptin (phosphate monohydrate) 654671-77-9 C16H20F6N5O6P 22
DBPR108 1186426-66-3 C16H25FN4O2 7
UAMC00039 (dihydrochloride) 697797-51-6 C16H26Cl3N3O 9

Recommended Products in the Same Indication

Name CAS Formula Suppliers
Glibenclamide 10238-21-8 C23H28ClN3O5S 30
Mitiglinide (Calcium) 145525-41-3 C38H50CaN2O7 24
Saxagliptin 361442-04-8 C18H25N3O2 22
Teneligliptin 760937-92-6 C22H30N6OS 12
Empagliflozin 864070-44-0 C23H27ClO7 22
MK 0893 870823-12-4 C32H27Cl2N3O4 10
Canagliflozin 842133-18-0 C24H25FO5S 24
Manidipine (dihydrochloride) 89226-75-5 C35H40Cl2N4O6 17
Teneligliptin (hydrobromide) 906093-29-6 C44H65Br5N12O2S2 13
Exendin-4 (Acetate) 914454-01-6 C186H286N50O62S 8
Trelagliptin 865759-25-7 C18H20FN5O2 18
Linagliptin 668270-12-0 C25H28N8O2 23
Bardoxolone (methyl) 218600-53-4 C32H43NO4 16
Emricasan 254750-02-2 C26H27F4N3O7 8
Alogliptin 850649-61-5 C18H21N5O2 14
Alogliptin (Benzoate) 850649-62-6 C25H27N5O4 21
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 6
Imeglimin (hydrochloride) 775351-61-6 C6H14ClN5 10
Imeglimin 775351-65-0 C6H13N5 10
Balaglitazone 199113-98-9 C20H17N3O4S 10

Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,66 mg/mL(197.94 mM);In vitro:Ethanol,66 mg/mL(197.94 mM);In vitro:Water,1 mg/mL(2.99 mM);
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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