Defactinib
(CAS: 1073154-85-4)
Background Information of Defactinib
Defactinib is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
Storage Condition of Defactinib
Quality Control and Spectral Data
Mechanism and Indications
Chemical Information
| M.Wt |
Formula |
CAS No. |
Synonyms |
| 510.49 |
C20H21F3N8O3S |
1073154-85-4 |
VS-6063;VS6063;VS 6063; N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide |
Structure Information of Defactinib
| Smiles |
O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1 |
| InChI |
InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) |
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Safety Data of Defactinib
Chemical and Physical Properties
| Appearance:White to off-white Solid |
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| Water Solubility: |
Solubility:In vitro:DMSO,5 mg/mLwarmed(9.79 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+50% PEG 300+5% Tween 80+ddH2OFor best results, |
| Density: |
Merck: |
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Refractive Index: |
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EINECS: |
| Optical Rotation: |
alpha: |
