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(CAS: 1073154-85-4)

Suppliers of Defactinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

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Price and Availability: USD17/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

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Active Biochem [email protected]; [email protected] 1-800-857-0985 (USA Toll Free#) USA

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Price and Availability: USD110/10mg ()

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD105/5mg (In stock)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Price and Availability: USD175/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD84/5mg () USD108/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Price and Availability: USD29/1mg ()

ChemieTek [email protected] +1 (317) 598-0828 USA

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Price and Availability: USD120/10mg () USD700/200mg ()

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

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Price and Availability: USD400/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD84/5mg () USD108/10mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Price and Availability: USD120/10mg ()

ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD84/5mg () USD108/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD101/5mg () USD198/10mg () USD356/25mg () USD546/50mg () USD899/100mg ()

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Background Information of Defactinib

Defactinib is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

Solubility of Defactinib

Solubility Sources
DMSO 50 mg/ml MedChemexpress Co., Ltd.

Storage Condition of Defactinib

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK
Target FAK
Research Area Cancer
Indications Non Hematologic Cancers

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Defactinib Verastem, Inc. Non Hematologic Cancers 2013/9/11 Phase 1 Clinical
Defactinib - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
510.49 C20H21F3N8O3S 1073154-85-4 VS-6063;VS6063;VS 6063; N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

Structure Information of Defactinib

Smiles O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1
InChI InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)

Related Products

Other Form Products of Defactinib

Name CAS Formula Suppliers
Defactinib (hydrochloride) 1073160-26-5 C20H22ClF3N8O3S 9

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Y15 4506-66-5 C6H14Cl4N4 23
NAMI-A 201653-76-1 C8H16Cl4N4ORuS 7
Defactinib (hydrochloride) 1073160-26-5 C20H22ClF3N8O3S 9
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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,5 mg/mLwarmed(9.79 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+50% PEG 300+5% Tween 80+ddH2OFor best results,
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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