Defactinib

(CAS: 1073154-85-4)

16	Quality Control and Spectral Data: 8 Solubility Information: 2 Storage Condition Information: 1 MSDS Information: 1 Related Products: Other Forms of Defactinib: 1 Recommended Products in the Same Target: 12 Recommended Products in the Same Indication: 0	Clinical and Indication Information: Phase 1 Clinical (Non Hematologic Cancers)

Suppliers of Defactinib

Company Name	Email	Tel	Country
AOBIOUS INC	[email protected]	(508) 306-0937	USA
Fax: Purity: Brand: AOBIOUS INC Price and Availability: USD17/1mg ()
Active Biochem	[email protected]; [email protected]	1-800-857-0985 (USA Toll Free#)	USA
Fax: 1-201-884-1288 (USA Fax#)Purity: Brand: Price and Availability: USD110/10mg ()
AdooQ BioScience, LLC	[email protected]	855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada)	USA
Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand: Price and Availability: USD320/5mg ()
Apexbio Technology LLC	[email protected]	+1-832-696-8203	USA
Fax: +1-832-641-3177Purity: Brand: Price and Availability: USD105/5mg (In stock)
BOC Sciences	[email protected]	1-631-504-6093
Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences
BioVision, Inc.,	[email protected]	408-493-1800 Toll Free: 800-891-9699 (US Only)	USA
Fax: 408-493-1801Purity: Brand: Price and Availability: USD175/5mg ()
Biochempartner Co., Ltd	[email protected]	0086-13720134139; 0086-15971444841	China
Fax: Purity: 98% Brand: Biochempartner
CHEMSCENE, LLC	[email protected]	732-484-9848	USA
Fax: 888-484-5008Purity: Brand: Price and Availability: USD84/5mg () USD108/10mg ()
Cayman Chemical Company	[email protected]	Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888	USA
Fax: (734) 971-3640Purity: Brand: Price and Availability: USD29/1mg ()
ChemieTek	[email protected]	+1 (317) 598-0828	USA
Fax: +1 (317) 598-0835Purity: Brand: Price and Availability: USD120/10mg () USD700/200mg ()
DC Chemicals	[email protected]; [email protected]	+86-21-58447131	China
Fax: +86-21-61642470Purity: Brand: Price and Availability: USD400/100mg (In stock)
MedChemexpress Co., Ltd.	[email protected]	609-228-6898	USA
Fax: 609-228-5909Purity: Brand: Price and Availability: USD84/5mg () USD108/10mg () Quality Control & MSDS Files: HNMR LCMS HNMR HNMR HNMR HNMR LCMS LCMS MSDS
MedKoo Biosciences, Inc.	[email protected]	919-279-0682	USA
Fax: 919-980-4831Purity: Brand: Price and Availability: USD120/10mg ()
Selleck Chemicals LLC	[email protected]	+1-832-582-8158	USA
Fax: +1-832-582-8590Purity: >98% Brand: Selleck
Shanghai Haoyuan Chemexpress Co., Ltd.	[email protected]	+86 (21) 5187-0955 / +86 (21) 5895-5995	China
Fax: +86 (21) 5895-5996Purity: Brand: Price and Availability: USD84/5mg () USD108/10mg ()
Target Molecule Corp.	[email protected]	(857) 239-0968	USA
Fax: 857-239-8801Purity: .98 Brand: TargetMol Price and Availability: USD101/5mg () USD198/10mg () USD356/25mg () USD546/50mg () USD899/100mg ()

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Background Information of Defactinib

Defactinib is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

Solubility of Defactinib

Solubility	Sources
DMSO 50 mg/ml	CHEMSCENE, LLC
DMSO 50 mg/ml	MedChemexpress Co., Ltd.

Storage Condition of Defactinib

Storage Condition	Sources
4°C	MedChemexpress Co., Ltd.

MSDS Information

MSDS	Sources
	MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports	Sources
[HNMR] [LCMS]	MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways	Protein Tyrosine Kinase/RTK

Target	FAK

Research Area	Cancer

Indications	Non Hematologic Cancers

Clinical Information

Product Name	Sponsor & Collaborators	Indications	Start Date	End Date	Phase
Defactinib	Verastem, Inc.	Non Hematologic Cancers	2013/9/11		Phase 1 Clinical
Defactinib	-				Phase 2

Chemical Information

M.Wt	Formula	CAS No.	Synonyms
510.49	C20H21F3N8O3S	1073154-85-4	VS-6063;VS6063;VS 6063; N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

Structure Information of Defactinib

Smiles	O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1
InChI	InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)

Related Products

Other Form Products of Defactinib

Name	CAS	Formula	Suppliers
Defactinib (hydrochloride)	1073160-26-5	C20H22ClF3N8O3S	5

Recommended Products in Same Target

Name	CAS	Formula	Suppliers
CEP-37440	1391712-60-9	C30H38ClN7O3	9
PND-1186	1061353-68-1	C25H26F3N5O3	13
PF-573228	869288-64-2	C22H20F3N5O3S	8
PF-562271 (besylate)	939791-38-5	C27H26F3N7O6S2	7
NVP-TAE 226	761437-28-9	C23H25ClN6O3	8
PF-431396	717906-29-1	C22H21F3N6O3S	5
PF-562271	717907-75-0	C21H20F3N7O3S	9
Y15	4506-66-5	C6H14Cl4N4	15
NAMI-A	201653-76-1	C8H16Cl4N4ORuS	4
Defactinib (hydrochloride)	1073160-26-5	C20H22ClF3N8O3S	5
GSK2256098	1224887-10-8	C20H23ClN6O2	5

Recommended Products in the Same Indication

Name	CAS	Formula	Suppliers

Safety Data of Defactinib

Hazard Symbols:	Risk Statements:	Safety Statements:
Transport Information:	HS Code:	RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid	Melting point:
Boiling point:	Flash Point:
Water Solubility:	Solubility:
Density:	Merck:
BRN:	Refractive Index:
Vapour:	EINECS:
Optical Rotation:	alpha:

Reference

[1].Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.

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