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(CAS: 1619903-54-6)

Suppliers of LY2857785

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Price and Availability: USD350/5mg (Ship Within 10-14 Days)

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD132/2mg () USD420/5mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD132/2mg () USD264/5mg ()

Shanghai XingMo Biotechnology Co., Ltd. [email protected] 13524779951 CHINA

Fax: Purity: > 98% Brand: X-MoBio

Price and Availability: USD950/1g (In stock)

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Background Information of LY2857785

LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9 (IC50 11 nM) and other transcription kinases CDK8 (IC50 16 nM), and CDK7 (IC50 246 nM).

Solubility of LY2857785

Solubility Sources
10 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of LY2857785

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LY2857785 - Not Found
LY2857785 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
448.6 C26H36N6O 1619903-54-6 LY 2857785;LY-2857785; (1r,4r)-N1-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine

Structure Information of LY2857785

Smiles CC(C1=C2C=C(C3=NC(N[[email protected]]4CC[[email protected]](NC5CCOCC5)CC4)=NC=C3)C=CC2=NN1C)C
InChI InChI=1S/C26H36N6O/c1-17(2)25-22-16-18(4-9-24(22)31-32(25)3)23-10-13-27-26(30-23)29-20-7-5-19(6-8-20)28-21-11-14-33-15-12-21/h4,9-10,13,16-17,19-21,28H,5-8,11-12,14-15H2,1-3H3,(H,27,29,30)/t19-,20-

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Ethanol,42 mg/mL(93.62 mM);In vitro:DMSO,23 mg/mL(51.27 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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