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AMG 837 (sodium salt)

(CAS: 865231-45-4)

Suppliers of AMG 837 (sodium salt)

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD156/5mg () USD228/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD156/5mg () USD228/10mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD156/5mg () USD228/10mg ()

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Background Information of AMG 837 (sodium salt)

AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively).

Solubility of AMG 837 (sodium salt)

Solubility Sources

Storage Condition of AMG 837 (sodium salt)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AMG 837 (sodium salt) - Not Found
AMG 837 (sodium salt) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
460.42 C26H20F3NaO3 865231-45-4 AMG-837 sodium salt;AMG837 sodium salt; sodium (S)-3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoate

Structure Information of AMG 837 (sodium salt)

Smiles O=C(O[Na])C[[email protected]](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2
InChI InChI=1S/C26H21F3O3.Na/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29;/h3,5-15,21H,16-17H2,1H3,(H,30,31);/q;+1/p-1/t21-;/m0./s1

Related Products

Other Form Products of AMG 837 (sodium salt)

Name CAS Formula Suppliers
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 6
AMG 837 865231-46-5 C26H21F3O3 11

Recommended Products in Same Target

Name CAS Formula Suppliers
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 6
GPR40 Activator 1 1309435-60-6 C31H31NO3S 5
AMG 837 865231-46-5 C26H21F3O3 11
TUG-770 1402601-82-4 C19H14FNO2 7
GW9508 885101-89-3 C22H21NO3 20
TAK-875 1000413-72-8 C29H32O7S 9
GW-1100 306974-70-9 C27H25FN4O4S 4
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 4
DC260126 346692-04-4 C32H31N5O 6
M-I C19H22O5S 0
T-1676427 1000414-39-0 C29H32O8S 0
JTT-851 C23H28O3 0
Astellas C27H30N4O4 0
MK-2305 C19H13ClF3NO4S 0
Mochida C30H35NO6S 0
BMS-986118 C25H28ClF3N4O4 0

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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