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AMG 837 (calcium hydrate)

(CAS: 1259389-38-2)

Suppliers of AMG 837 (calcium hydrate)

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD80/5mg ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD132/5mg () USD204/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD132/5mg () USD204/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD132/5mg () USD204/10mg ()

Shanghai XingMo Biotechnology Co., Ltd. [email protected] 13524779951 CHINA

Fax: Purity: > 98% Brand: X-MoBio

Price and Availability: USD1400/1g (In stock)

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Background Information of AMG 837 (calcium hydrate)

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively).

Solubility of AMG 837 (calcium hydrate)

Solubility Sources

Storage Condition of AMG 837 (calcium hydrate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AMG 837 (calcium hydrate) - Not Found
AMG 837 (calcium hydrate) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
455.45 C26H22F3O4- 1259389-38-2 AMG-837 calcium hydrate;AMG837 calcium hydrate;

Structure Information of AMG 837 (calcium hydrate)

Smiles [O-]C(C[[email protected]](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O.[0.5Ca].O
InChI

Related Products

Other Form Products of AMG 837 (calcium hydrate)

Name CAS Formula Suppliers
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 5
AMG 837 865231-46-5 C26H21F3O3 11

Recommended Products in Same Target

Name CAS Formula Suppliers
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 5
GPR40 Activator 1 1309435-60-6 C31H31NO3S 5
AMG 837 865231-46-5 C26H21F3O3 11
TUG-770 1402601-82-4 C19H14FNO2 7
GW9508 885101-89-3 C22H21NO3 20
TAK-875 1000413-72-8 C29H32O7S 9
GW-1100 306974-70-9 C27H25FN4O4S 4
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 4
DC260126 346692-04-4 C32H31N5O 6
M-I C19H22O5S 0
T-1676427 1000414-39-0 C29H32O8S 0
JTT-851 C23H28O3 0
Astellas C27H30N4O4 0
MK-2305 C19H13ClF3NO4S 0
Mochida C30H35NO6S 0
BMS-986118 C25H28ClF3N4O4 0

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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