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(ML293fzc)

1

Identification

ML293fzc ML293fzc
Name ML293fzc
Formula C16H14N2O2S
MW 298.36
CAS No.
EINECS
Smiles C1(OC)C2N=C(C(NC3C=CC=CC=3)=O)SC=2C(C)=CC=1
Synonyms
InChI InChI=1S/C16H14N2O2S/c1-10-8-9-12(20-2)13-14(10)21-16(18-13)15(19)17-11-6-4-3-5-7-11/h3-9H,1-2H3,(H,17,19)
2

Introduction

ML293 is a potent and selective M4 positive allosteric modulator (PAM). Muscarinic acetylcholine receptors (mAChRs) have five distinct subunits (M1-M5) and are involved in the action of the neurotransmitter acetylcholine in the central and peripheral nervous system. The development of M4-selective PAMs is a novel strategy to overcome the challenges associated with subtype-selective orthosteric muscarinic agonists.

Background Information

3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB100692192

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of ML293fzc

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

ML293fzc

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