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2148928-82-7 (VU6009454)

1

Identification

VU6009454 VU6009454
Name VU6009454
Formula C21H19F3N4O
MW 400.4
CAS No. 2148928-82-7
EINECS
Smiles C1C(C)=C2C=C(C(NC3CN(C4C=NC(C(F)(F)F)=CC=4)C3)=O)C=CC2=NC=1C
Synonyms
InChI InChI=1S/C21H19F3N4O/c1-12-7-13(2)26-18-5-3-14(8-17(12)18)20(29)27-15-10-28(11-15)16-4-6-19(25-9-16)21(22,23)24/h3-9,15H,10-11H2,1-2H3,(H,27,29)
2

Introduction

VU6009454 is an muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM) with an EC50 of 449 nM for rM4. M4 PAMs have garnered a great deal of attention as a new therapeutic approach for the treatment of schizophrenia (both the positive and cognitive symptom clusters), Huntington’s disease and Parkinson’s disease.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB100166971

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of VU6009454

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of 2148928-82-7

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

VU6009454

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