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(RG-12)

1

Identification

RG-12 RG-12
Name RG-12
Formula C24H20F3NO5S2
MW 523.54
CAS No.
EINECS
Smiles C1C(S(C(F)(F)F)(=O)=O)=C2CC3(S(C4C=CC=CC=4)(=O)=O)C(=O)C4N(C3C3C=CC=CC=34)[[email protected]]2([H])CC1 |&1:32|
Synonyms
InChI InChI=1S/C24H20F3NO5S2/c25-24(26,27)35(32,33)19-12-6-11-18-17(19)13-23(34(30,31)14-7-2-1-3-8-14)21-16-10-5-4-9-15(16)20(22(23)29)28(18)21/h1-5,7-10,18,20-21H,6,11-13H2/t18-,20?,21?,23?/m1/s1
2

Introduction

RG-12 is a M1, M3, and M5-muscarinic acetylcholine receptors (mAChRs) antagonist with pIC50s of 6.890±0.25, 5.500±0.318, and 6.570±0.26, respectively.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB100145228

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of RG-12

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

RG-12

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