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1000025-07-9 (Vadadustat)

1

Identification

Vadadustat Vadadustat
Name Vadadustat
Formula C14H11ClN2O4
MW 0.0
CAS No. 1000025-07-9
EINECS
Smiles O=C(O)CNC(C1=NC=C(C2=CC=CC(Cl)=C2)C=C1O)=O
Synonyms PG-1016548;PG1016548;PG 1016548; 2-(5-(3-chlorophenyl)-3-hydroxypicolinamido)acetic acid
InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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Introduction

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Background Information

Vadadustat is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor, which leads to stabilization and increased levels of HIFα. It is used for the treatment of anemia caused by secondary chronic kidney disease. It was developed by Akebia Therape ......by BOC Sciences
Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. ......by MedChemexpress Co., Ltd.
Vadadustat, also known as AKB-6548 and PG-1016548, is a potent Hypoxia-inducible factor-proline dioxygenase inhibitor. AKB-6548 works by inhibiting hypoxia inducible factor-prolyl hydroxylase (HIP-PH), leading to stabilization and increased levels of HIFα. In turn HIFα improves production of hemoglobin and red blood cells (RBCs), while maintaining normal levels of erythropoietin (EPO) in patients. We believe this differentiated mechanism of action has the potential to be safer than that of injectable recombinant erythropoietin stimulating agents (rESAs), avoiding supra-physiological levels of EPO and saturation of EPO receptors for prolonged periods of time. ......by MedKoo Biosciences, Inc.
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF-PH inhibitor in development for the treatment of anemia in both nondialysis-dependent (NDD) and dialysis-dependent CKD; induces endogenous erythropoietin synthesis and enhances iron mobilization.AnemiaPhase 3 Clinical ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000124124

Storage condition

Solubility

DMSO: ≥ 33 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 33 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vadadustat Akebia Therapeutics Healthy Volunteers 2014/12/1 Phase 1
Vadadustat Akebia Therapeutics Anemia|Kidney Disease 2010/10/1 Phase 2
Vadadustat Akebia Therapeutics Healthy Volunteers 2015/7/1 Phase 1
Vadadustat Akebia Therapeutics Healthy Volunteers 2014/1/1 Phase 1
Vadadustat Akebia Therapeutics Anemia|Kidney Disease 2011/6/1 Phase 2
Vadadustat Akebia Therapeutics Healthy 2015/4/1 Phase 1
Vadadustat Akebia Therapeutics Anemia|Chronic Kidney Disease 2013/7/1 Phase 2
Vadadustat Akebia Therapeutics Anemia|End Stage Renal Disease 2014/9/1 Phase 2
Vadadustat Akebia Therapeutics Anemia|Dialysis-Dependent Chronic Kidney Disease 2017/5/23 Phase 2
Vadadustat Akebia Therapeutics Anemia; Dialysis Dependent Chronic Kidney Disease 2016/12/1 Phase 2
Vadadustat Akebia Therapeutics Anemia; Non-dialysis Dependent Chronic Kidney Disease 2016/10/1 Phase 2
Vadadustat Akebia Therapeutics Anemia|Non-dialysis-dependent Chronic Kidney Disease 2015/12/1 Phase 3
Vadadustat Akebia Therapeutics Anemia|Dialysis-dependent Chronic Kidney Disease 2016/7/1 Phase 3
Vadadustat Akebia Therapeutics Anemia|Non-dialysis-dependent Chronic Kidney Disease 2016/2/1 Phase 3
Vadadustat Akebia Therapeutics Anemia in Subjects With DD-CKD 2016/8/1 Phase 3
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Safety Data of Vadadustat

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 2mg/USD70();5mg/USD120() USA
MedChemexpress Co., Ltd. 2mg/USD70();5mg/USD120() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 2mg/USD70();5mg/USD120() China
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Related Products

Other Forms of 1000025-07-9

Name CAS No Formula MW

Recommended Compounds in HIF/HIF Prolyl-Hydroxylase

Name CAS No Formula MW
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
DMOG 89464-63-1 C6H9NO5 175.14
Hydralazine (hydrochloride) 304-20-1 C8H9ClN4 196.64
BAY 87-2243 1227158-85-1 C26H26F3N7O2 525.53
Oroxylin A 480-11-5 C16H12O5 284.26
Paeoniflorin 23180-57-6 C23H28O11 480.46
LW6 934593-90-5 C26H29NO5 435.51
Chlorogenic acid 327-97-9 C16H18O9 354.31
FG-4592 808118-40-3 C19H16N2O5 352.34
IOX2 931398-72-0 C19H16N2O5 352.34
ENMD-119 864668-87-1 C20H25NO2 311.42
EL-102 1233948-61-2 C19H16N2O3S2 384.47
PX-478 685898-44-6 C13H20Cl4N2O3 394.12
2-Methoxyestradiol 362-07-2 C19H26O3 302.41
Acriflavine 8048-52-0 C14H14ClN3 259.73
AKBA 67416-61-9 C32H48O5 512.7205
HIF-2α-IN-1 1799948-06-3 C16H8F5NO4S 405.2961
THS-044 62054-67-5 C11H12F3N3O3 291.23
DASA-58 1203494-49-8 C19H23N3O6S2 453.53
Daprodustat 960539-70-2 C19H27N3O6 393.43

Recommended Compounds in Same Indication

Name CAS No Formula MW
VGX-1027 6501-72-0 C11H11NO3 205.21
AZD1981 802904-66-1 C19H17ClN2O3S 388.87
4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- 854107-55-4 C22H23ClN2O4S 446.95
Avatrombopag 570406-98-3 C29H34Cl2N6O3S2 649.65
RSV604 676128-63-5 C22H17FN4O2 388.39
Cilobradine (hydrochloride) 186097-54-1 C28H39ClN2O5 519.07
Vipadenant 442908-10-3 C16H15N7O 321.3366
Brivaracetam 357336-20-0 C11H20N2O2 212.2887
Cilobradine 147541-45-5 C28H38N2O5 482.61
PF-04418948 1078166-57-0 C23H20FNO5 409.41
JNJ-40411813 1127498-03-6 C20H25ClN2O 344.88
GLPG0634 1206161-97-8 C21H23N5O3S 425.504
GLPG0492 1215085-92-9 C19H14F3N3O3 389.328
BI 224436 1155419-89-8 C27H26N2O4 442.51
Heparin 9005-49-6 C26H42N2O37S5 1134.93
MGB-BP-3 1000277-08-6 C36H37N7O4 631.72
VITAMIN K1 12001-79-5 C31H46O2 450.7
Tenapanor 1234423-95-0 C50H66Cl4N8O10S2 1145.05
GLPG0187 1320346-97-1 C29H37N7O5S 595.71
Iberdomide 1323403-33-3 C25H27N3O5 449.49898
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Route of Synthesis

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References

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More Information

Vadadustat

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