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749269-83-8 (CHF5074)

1

Identification

CHF5074 CHF5074
Name CHF5074
Formula C16H11Cl2FO2
MW 325.1617
CAS No. 749269-83-8
EINECS
Smiles OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O
Synonyms CSP-1103;Itanapraced
InChI InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)
2

Introduction

CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.

Background Information

a γ-secretase modulator ......by AOBIOUS INC
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. ......by AdooQ BioScience, LLC
CHF5074, also known as CSP-1103, is a novel γ-secretase modulator. It could reduce Aβ42 and Aβ40 secretion, which IC50 value is 3.6 and 18.4 μM respectively. It induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures ......by BOC Sciences
CHF5074, also known as CSP-1103, is a γ-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro. CHF5074 induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice. ......by MedKoo Biosciences, Inc.
CHF-5074 is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. ......by MedKoo Biosciences, Inc.
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023313

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO:37mg/mL by CHEMSCENE, LLC
DMSO:37mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling Stem Cell/Wnt
Target γ-secretase
Research Area Neurological Disease
Indications Alzheimer's Disease
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
CHF5074 CERESPIR Alzheimer's Disease 2011/2/23 2015/2/1 Phase 2 Clinical
CHF5074 - Phase 1
7

Safety Data of CHF5074

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD53() USA
AdooQ BioScience, LLC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 5mg/USD420();10mg/USD600() USA
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD600() USA
MedKoo Biosciences, Inc. USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD600() China
Target Molecule Corp. 2mg/USD222();5mg/USD346();10mg/USD498();50mg/USD1470() USA
10

Related Products

Other Forms of 749269-83-8

Name CAS No Formula MW

Recommended Compounds in γ-secretase

Name CAS No Formula MW
LY-411575 (isomer 1) 209984-58-7 C26H23F2N3O4 479.48
YO-01027 209984-56-5 C26H23F2N3O3 463.48
gamma-secretase modulator 3 1431697-84-5 C24H23FN4OS 434.53
BMS 433796 935525-13-6 C19H16F2N4O4 402.35
BMS 299897 290315-45-6 C24H21ClF3NO4S 511.94
ELN 318463 851600-86-7 C19H20BrClN2O3S 471.8
MRK 003 623165-93-5 C25H31F6N3O2S 551.59
PF-3084014 1290543-63-3 C27H41F2N5O 489.64
Begacestat 769169-27-9 C9H8ClF6NO3S2 391.74
RO4929097 847925-91-1 C22H20F5N3O3 469.4
gamma-secretase modulator 1 1172637-87-4 C24H24N4OS 416.54
gamma-secretase modulator 2 1093978-89-2 C25H22F4N6O2 514.47
LY-411575 209984-57-6 C26H23F2N3O4 479.48
E 2012 870843-42-8 C25H26FN3O2 419.49
Semagacestat 425386-60-3 C19H27N3O4 361.44
DAPT 208255-80-5 C23H26F2N2O4 432.46
MK-0752 471905-41-6 C21H21ClF2O4S 442.9
BMS-708163 1146699-66-2 C20H17ClF4N4O4S 520.89
L-685458 292632-98-5 C39H52N4O6 672.85
Z-Ile-Leu-aldehyde 161710-10-7 C20H30N2O4 362.46

Recommended Compounds in Same Indication

Name CAS No Formula MW
Azeliragon 603148-36-3 C32H38ClN3O2 532.116
LY451395 375345-95-2 C21H30N2O4S2 438.6
MSDC 0160 146062-49-9 C19H18N2O4S 370.42
THK5351 1707147-26-9 C18H18FN3O2 0.0
MK-0249 862309-06-6 C23H24F3N3O2 431.45
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Route of Synthesis

12

References

13

More Information

CHF5074

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