• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1201438-56-3 (Duvelisib)

1

Identification

Duvelisib Duvelisib
Name Duvelisib
Formula C22H17ClN6O
MW 416.863
CAS No. 1201438-56-3
EINECS
Smiles O=C1N(C2=CC=CC=C2)C([[email protected]@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5
Synonyms IPI-145;INK1197
InChI InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
2

Introduction

Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.

Background Information

An orally bioavailable PI3K/P110 isoform-specific inhibitor ......by AOBIOUS INC
IPI-145 is a novel and selective PI3K δ/γ inhibitor with IC50 of 23 pM and 243 pM, respectively. IPI-145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM. IPI-145 was well tolerated and clinically active in a broad range of malignancies, including iNHL. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. ......by AbMole BioScience
IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. ......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activitie ......by BOC Sciences
IPI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the PI3Kd/γ-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3Kd/γ-expressing tumor cells. ......by BioVision, Inc.,
Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively. ......by MedChemexpress Co., Ltd.
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. ......by MedKoo Biosciences, Inc.
A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM; displays high selectivity for PI3K δ/γ than other protein kinases; exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation; exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.Blood CancerPhase 3 Clinical ......by ProbeChem
Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3. ......by Selleck Chemicals LLC
Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018151

Storage condition

Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 83 mg/mL (199.1 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Duvelisib Infinity Pharmaceuticals Inc Asthma 2012/7/31 2013/9/30 Phase 2 Clinical
Duvelisib Infinity Pharmaceuticals Inc Non-Hodgkin lymphoma 2013/5/31 2017/11/30 Phase 2 Clinical
Duvelisib Infinity Pharmaceuticals Inc Rheumatoid arthritis 2013/4/30 2014/7/31 Phase 2 Clinical
Duvelisib Sarah Cannon Research Institute Chronic lymphocytic leukemia 2013/5/31 2015/6/30 Phase 1 Clinical
Duvelisib Infinity Pharmaceuticals Inc Hematological neoplasm 2011/10/31 2014/5/31 Phase 1 Clinical
Duvelisib - Phase 3
7

Safety Data of Duvelisib

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AOBIOUS INC 1mg/USD23() USA
AbMole BioScience 10mg/USD150(In stock) USA
Active Biochem 5mg/USD100() USA
Adipogen Corporation USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC 5mg/USD80(In Stock) USA
Ark Pharm, Inc. 1g/USD980(In Stock) USA
BLD Pharmatech
BOC Sciences 100mg/USD228(In stock)
BioVision, Inc., 5mg/USD125() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD96();10mg/USD132() USA
Cayman Chemical Company 500ug/USD55() USA
LC Laboratoies 5mg/USD67(In stock);10mg/USD99(In stock);25mg/USD158(In stock);50mg/USD237(In stock);100mg/USD415(In stock);200mg/USD675(In stock);500mg/USD1480(In stock) USA
Lancrix Chemicals. 10mg/USD308();50mg/USD925() China
MedChemexpress Co., Ltd. 5mg/USD96();10mg/USD132() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Pure Chemistry Scientific Inc. 5mg/USD117(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD300() USA
Selleck Chemicals LLC 5mg/USD170(In stock);10mM/1mLIn DMSO/USD190(In stock);10mM(in 1mL DMSO)/USD239(in 1mL DMSO);50mg/USD970(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD96();10mg/USD132() China
Target Molecule Corp. 10mg/USD120();50mg/USD365() USA
10

Related Products

Other Forms of 1201438-56-3

Name CAS No Formula MW
Duvelisib (R enantiomer) 1261590-48-0 C22H17ClN6O 416.86

Recommended Compounds in PI3K

Name CAS No Formula MW
MLN1117 1268454-23-4 C19H17N5O3 363.37
TGR-1202 1532533-67-7 C31H24F3N5O3 571.55
PI-3065 955977-50-1 C27H31FN6OS 506.64
Isorhamnetin 480-19-3 C16H12O7 316.26
BSF-466895 262442-90-0 C29H32Cl2FN7O2S 632.58
SAR245409 934493-76-2 C13H14N6O 270.29
HS-173 1276110-06-5 C21H18N4O4S 422.46
GDC-0032 1282512-48-4 C24H28N8O2 460.53
PF-4989216 1276553-09-3 C18H13FN6OS 380.4
CAL-130 (Hydrochloride) 1431697-78-7 C23H23ClN8O 462.93
CNX-1351 1276105-89-5 C30H35N7O3S 573.71
Quercetin 117-39-5
AS-252424 900515-16-4 C14H8FNO4S 305.28
CAY10505 1218777-13-9 C14H8FNO3S 289.28
CUDC-907 1339928-25-4 C23H24N8O4S 508.55
CAL-130 1431697-74-3 C23H22N8O 426.47
VS-5584 1246560-33-7 C17H22N8O 354.41
CH5132799 1007207-67-1 C15H19N7O3S 377.42
XL-147 934526-89-3 C25H25ClN6O4S 541.02
NVP-QAV-572 957209-68-6 C17H19F2N7O3S2 471.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
Vidofludimus 717824-30-1 C20H18FNO4 355.36
Mocetinostat 726169-73-9 C23H20N6O 396.44
CAL-101 870281-82-6 C22H18FN7O 415.42
PU-H71 873436-91-0 C18H21IN6O2S 512.37
R406 (free base) 841290-80-0 C22H23FN6O5 470.45
R406 841290-81-1 C28H29FN6O8S 628.63
AT9283 896466-04-9 C19H23N7O2 381.43
R788 901119-35-5 C23H26FN6O9P 580.46
SNX-2112 908112-43-6 C23H27F3N4O3 464.48
R788 (disodium hexahydrate) 914295-16-2 C23H24FN6Na2O9P 624.42
Itacitinib 1334298-90-6 C26H23F4N9O 553.5142
SCH 527123 473727-83-2 C21H23N3O5 397.42
Beclometasone dipropionate 5534-09-8 C28H37ClO7 521.04
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
Methotrexate 59-05-2 C20H22N8O5 454.44
N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide 414864-00-9 C15H14N2O4S 318.34766
Setipiprant 866460-33-5 C24H19FN2O3 402.42
FK866 658084-64-1 C24H29N3O2 391.51
Levalbuterol (tartrate) 661464-94-4 C30H48N2O12 628.71
17-AAG (Hydrochloride) 911710-03-7 C31H44ClN3O8 622.15
11

Route of Synthesis

12

References

13

More Information

Duvelisib

Tags: buy 1201438-56-3 IC50 | 1201438-56-3 price | 1201438-56-3 cost | 1201438-56-3 solubility | 1201438-56-3 purchase | 1201438-56-3 manufacturer | 1201438-56-3 research buy | 1201438-56-3 order | 1201438-56-3 MSDS | 1201438-56-3 chemical structure | 1201438-56-3 Storage condition | 1201438-56-3 molecular weight | 1201438-56-3 mw | 1201438-56-3 datasheet | 1201438-56-3 supplier | 1201438-56-3 cell line | 1201438-56-3 NMR | 1201438-56-3 MS | 1201438-56-3 IR | 1201438-56-3 solubility | 1201438-56-3 Safe information | 1201438-56-3 Qc and Spectral Information | 1201438-56-3 Clinical Information | 1201438-56-3 Clinical Trial | 1201438-56-3 Route of Synthesis | 1201438-56-3 storage condition | 1201438-56-3 diseases and conditions | 1201438-56-3 flash point | 1201438-56-3 boiling point | 1201438-56-3 melting point | 1201438-56-3 storage condition | 1201438-56-3 brand