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149-64-4 (Scopolamine (butylbromide))

1

Identification

Scopolamine (butylbromide) Scopolamine (butylbromide)
Name Scopolamine (butylbromide)
Formula C21H30BrNO4
MW 440.37
CAS No. 149-64-4
EINECS 205-744-1
Smiles C[[email protected]+]1(CCCC)[[email protected]@]2([H])[[email protected]](O3)([H])[[email protected]]3([H])[[email protected]]1([H])C[[email protected]](OC([[email protected]](CO)C4=CC=CC=C4)=O)C2.[Br-]
Synonyms (-)-N-Butylscopolamine bromide; Hyoscine N-butyl bromide; (1R,2R,4S,5S,7s,9S)-9-butyl-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
InChI InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22+;/m1./s1
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Introduction

Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM. Target: mAChR Scopolamine (USAN), also known as levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects.

Background Information

Butylscopolamine BR is an orally available bromide salt form of butylscopolamine which is a peripherally acting antimuscarinic, anticholinergic agent. ......by AdooQ BioScience, LLC
Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system. The central effects include hallucinations, disorientation, restlessness and euphoria. Scopolamine disturb the stimulus detection performance in ......by BOC Sciences
Butylscopolamine bromide is an antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract. ......by MedKoo Biosciences, Inc.
Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:white EBNumber:EB000013554

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
DMSO 88 mg/mL (199 mM) ; Water 88 mg/mL (199 mM) ; Ethanol 23 mg/mL (52 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Scopolamine (butylbromide) - Launched
Scopolamine (butylbromide) - Phase 4
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Safety Data of Scopolamine (butylbromide)

Hazard Symbols : Xn
Risk Statements : 22
RTECS : YM3500000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Alkaloids Corporation India
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 100mg/USD60();500mg/USD96() USA
Guangzhou Bairui Medicine Co., Ltd. China
Jai Radhe Sales India
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD96() USA
MedKoo Biosciences, Inc. USA
N&R Industries, Inc. China
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD420(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD96() China
Target Molecule Corp. 10mg/USD22();50mg/USD75();100mg/USD138();250mg/USD218() USA
Wenling Tongda Fine Chemical Co., Ltd CHINA
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Related Products

Other Forms of 149-64-4

Name CAS No Formula MW
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26
Scopolamine 51-34-3 C17H21NO4 303.35

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Scopolamine (butylbromide)

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