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1402836-58-1 (NLG-919)

1

Identification

NLG-919 NLG-919
Name NLG-919
Formula
MW
CAS No. 1402836-58-1
EINECS
Smiles
Synonyms 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol; 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
InChI
2

Introduction

Background Information

NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this age ......by BOC Sciences
IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor (IC50=38 nM) ......by MedChemexpress Co., Ltd.
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1. ......by Selleck Chemicals LLC
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013139

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO 15 mg/mL heating; Water < 1 mg/ml by CHEMSCENE, LLC
DMSO 15 mg/mL heating; Water < 1 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 15 mg/mL warming (53.11 mM); Ethanol30 mg/mL (106.23 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
NLG-919 NewLink Genetics Corporation Solid Tumors 2014/1/10 Phase 1 Clinical
NLG-919 NewLink Genetics Corporation Breast Cancer 2014/1/10 Phase 1 Clinical
NLG-919 NewLink Genetics Corporation Pancreatic Cancer 2014/1/10 Phase 1 Clinical
NLG-919 - No Development Reported
7

Safety Data of NLG-919

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 10mg/USD120(Out of stock) USA
Apexbio Technology LLC 10mg/USD119(In stock) USA
BOC Sciences 50mg/USD199(In stock)
BioVision, Inc., 5mg/USD115() USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD108();50mg/USD288() USA
DC Chemicals 100mg/USD200(In stock) China
Lancrix Chemicals. 100mg/USD398() China
MedChemexpress Co., Ltd. 10mg/USD108();50mg/USD288() USA
MedKoo Biosciences, Inc. 10mg/USD90() USA
Pure Chemistry Scientific Inc. 250mg/USD1022(In stock) USA
Santa Cruz Biotechnology, Inc. 10mg/USD300() USA
Selleck Chemicals LLC 10mg/USD170(In stock);50mg/USD570(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD108();50mg/USD288() China
Sigma-Aldrich, Inc. USA
Target Molecule Corp. 10mg/USD102();25mg/USD168();50mg/USD258() USA
10

Related Products

Other Forms of 1402836-58-1

Name CAS No Formula MW

Recommended Compounds in Indoleamine 2,3-Dioxygenase (IDO)

Name CAS No Formula MW
IDO5L 914471-09-3 C9H7ClFN5O2 271.6356
β-Lapachone 4707-32-8 C15H14O3 242.2699
IDO-IN-8 1402837-77-7 C18H21FN2O2 316.37
Navoximod 1402837-78-8 C18H21FN2O2 316.3699
IDO-IN-6 1402837-76-6 C18H21FN2O2 316.37
IDO-IN-5 1402837-79-9 C18H21FN2O2 316.37
IDO-IN-4 1629125-65-0 C26H35N3O3 437.57
Indoximod 110117-83-4 C12H14N2O2 218.25
IDO-IN-1 914638-30-5 C9H7BrFN5O2 316.09
INCB 024360 1204669-58-8 C11H13BrFN7O4S 438.23
IDO-IN-2 1668565-74-9 C29H35N7O 497.63
8-Nitrotryptanthrin 77603-42-0 C15H7N3O4 293.23
PF-06840003 198474-05-4 C12H9FN2O2 0.0
1-methyl-tryptophan 26988-72-7 C12H14N2O2 218.25
IDO1-IN-1 C16H21Cl2N3O2 358.26
IDO1-IN-2 C16H21Cl2N3O2 358.26
IDO1-IN-11 2079883-26-2 C15H13Br2N3OS 443.16
IDO1-IN-3 C14H12BrN3O3S 382.23
IDO-IN-7 1402836-58-1 C18H22N2O 282.3801
IDO1-IN-5 C14H11F2N5O 303.27

Recommended Compounds in Same Indication

Name CAS No Formula MW
MSX-122 897657-95-3 C16H16N6 292.34
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Exatecan 171335-80-1 C24H22FN3O4 435.45
Exatecan (Mesylate) 169869-90-3 C25H26FN3O7S 531.55
NKP-1339 197723-00-5 C14H12Cl4N4NaRu 502.14
Didox 69839-83-4 C7H7NO4 169.13
Rucaparib 283173-50-2 C19H18FN3O 323.36
Rucaparib (phosphate) 459868-92-9 C19H21FN3O5P 421.36
Marimastat 154039-60-8 C15H29N3O5 331.4079
Gemcitabine (elaidate) 210829-30-4 C27H43F2N3O5 527.6442
Talabostat (mesylate) 150080-09-4 C10H23BN2O6S 310.18
Rimantadine (hydrochloride) 1501-84-4 0.0
SAR245409 934493-76-2 C13H14N6O 270.29
Oprozomib 935888-69-0 C25H32N4O7S 532.61
Dolastatin 10 110417-88-4 C42H68N6O6S 785.09
VITAMIN K1 12001-79-5 C31H46O2 450.7
GLPG0187 1320346-97-1 C29H37N7O5S 595.71
BGB-283 1446090-77-2 C25H17F3N4O3 478.42
Edotecarin 174402-32-5 C29H28N4O11 608.55
Lurbinectedin 497871-47-3 C41H44N4O10S 784.87
11

Route of Synthesis

12

References

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More Information

NLG-919

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