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247257-48-3 (Fimasartan)

1

Identification

Fimasartan Fimasartan
Name Fimasartan
Formula C27H31N7OS
MW 501.65
CAS No. 247257-48-3
EINECS
Smiles O=C1N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(CCCC)=NC(C)=C1CC(N(C)C)=S
Synonyms 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one; 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
InChI InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)
2

Introduction

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

Background Information

Fimasartan, also called as BR-A657, approved for the treatment of mild to moderate hypertension in South Korea, is a novel, non-peptide angiotensin II (Ang II) receptor antagonist with a selective type I (AT1) receptor blockade effect. Radioligand binding ......by BOC Sciences
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. Fimasartan was approved for use in South Korea in September 9th, 2010. ......by MedKoo Biosciences, Inc.
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure. ......by Selleck Chemicals LLC
Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000062358

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO:49mg/mL by CHEMSCENE, LLC
DMSO:49mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Angiotensin Receptor
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fimasartan - Launched
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Safety Data of Fimasartan

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AEchem Scientific Corporation USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD90() USA
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD90() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD90() China
Target Molecule Corp. 2mg/USD59();5mg/USD88();10mg/USD145();50mg/USD432() USA
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Related Products

Other Forms of 247257-48-3

Name CAS No Formula MW
Fimasartan (Potassium Trihydrate) 1020110-23-9 C27H37KN7O4S+ 594.79

Recommended Compounds in Angiotensin Receptor

Name CAS No Formula MW
Eprosartan (mesylate) 144143-96-4 C24H28N2O7S2 520.62
Losartan (potassium) 124750-99-8 C22H22ClKN6O 461.0
Losartan 114798-26-4 C22H23ClN6O 422.91
Candesartan (Cilexetil) 145040-37-5 C33H34N6O6 610.66
Candesartan 139481-59-7 C24H20N6O3 440.45
Irbesartan 138402-11-6 C25H28N6O 428.53
Tranilast (Sodium) 104931-56-8 C18H16NNaO5 349.31
Tranilast 53902-12-8 C18H17NO5 327.33
AVE 0991 (sodium salt) 306288-04-0 C29H31N4NaO5S2 602.7
AVE 0991 304462-19-9 C29H32N4O5S2 580.72
Telmisartan 144701-48-4 C33H30N4O2 514.62
Azilsartan (medoxomil monopotassium) 863031-24-7 C30H24KN4O8+ 607.63
Angiotensin II human 4474-91-3 C50H71N13O12 0.0
PD 123319 (ditrifluoroacetate) 136676-91-0 C35H34F6N4O7 736.66
Valsartan 137862-53-4 C24H29N5O3 435.52
Azilsartan 147403-03-0 C25H20N4O5 456.45
Azilsartan (medoxomil) 863031-21-4 C30H24N4O8 568.53
PD 123319 130663-39-7 C31H32N4O3 508.61
Olmesartan (medoxomil) 144689-63-4 C29H30N6O6 558.59
Olmesartan 144689-24-7 C24H26N6O3 446.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Fimasartan

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