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247257-48-3 (Fimasartan)

1

Identification

Fimasartan Fimasartan
Name Fimasartan
Formula C27H31N7OS
MW 501.65
CAS No. 247257-48-3
EINECS
Smiles O=C1N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(CCCC)=NC(C)=C1CC(N(C)C)=S
Synonyms 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one; 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
InChI InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)
2

Introduction

Background Information

Fimasartan, also called as BR-A657, approved for the treatment of mild to moderate hypertension in South Korea, is a novel, non-peptide angiotensin II (Ang II) receptor antagonist with a selective type I (AT1) receptor blockade effect. Radioligand binding ......by BOC Sciences
Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000062358

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO:49mg/mL by CHEMSCENE, LLC
DMSO:49mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Angiotensin Receptor
Research Area Cardiovascular Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fimasartan - Launched
7

Safety Data of Fimasartan

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AEchem Scientific Corporation USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD90() USA
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD90() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD90() China
Target Molecule Corp. 2mg/USD59();5mg/USD88();10mg/USD145();50mg/USD432() USA
10

Related Products

Other Forms of 247257-48-3

Name CAS No Formula MW
Fimasartan (Potassium Trihydrate) 1020110-23-9 C27H37KN7O4S+ 594.79

Recommended Compounds in Angiotensin Receptor

Name CAS No Formula MW
Eprosartan (mesylate) 144143-96-4 C24H28N2O7S2 520.62
Losartan (potassium) 124750-99-8 C22H22ClKN6O 461.0
Losartan 114798-26-4 C22H23ClN6O 422.91
Candesartan (Cilexetil) 145040-37-5 C33H34N6O6 610.66
Candesartan 139481-59-7 C24H20N6O3 440.45
Irbesartan 138402-11-6 C25H28N6O 428.53
Tranilast (Sodium) 104931-56-8 C18H16NNaO5 349.31
Tranilast 53902-12-8 C18H17NO5 327.33
AVE 0991 (sodium salt) 306288-04-0 C29H31N4NaO5S2 602.7
AVE 0991 304462-19-9 C29H32N4O5S2 580.72
Telmisartan 144701-48-4 C33H30N4O2 514.62
Azilsartan (medoxomil monopotassium) 863031-24-7 C30H24KN4O8+ 607.63
Angiotensin II human 4474-91-3 0.0
PD 123319 (ditrifluoroacetate) 136676-91-0 C35H34F6N4O7 736.66
Valsartan 137862-53-4 C24H29N5O3 435.52
Azilsartan 147403-03-0 C25H20N4O5 456.45
Azilsartan (medoxomil) 863031-21-4 C30H24N4O8 568.53
PD 123319 130663-39-7 C31H32N4O3 508.61
Olmesartan (medoxomil) 144689-63-4 C29H30N6O6 558.59
Olmesartan 144689-24-7 C24H26N6O3 446.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Fimasartan

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