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51-45-6 (Histamine)



Histamine Histamine
Name Histamine
Formula C5H9N3
MW 111.15
CAS No. 51-45-6
EINECS 200-100-6
Smiles NCCC1=CNC=N1
Synonyms 1H-Imidazole-4-ethanamine; 2-(4-Imidazolyl)ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 2-(1H-imidazol-4-yl)ethanamine
InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)


Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.

Background Information

Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. ......by AbMole BioScience
Histamine is an organic nitrogenous compound produced by basophils and by mast cells found in nearby connective tissues. ......by BOC Sciences
Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist. ......by Selleck Chemicals LLC
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000029208

Storage condition

4°C by MedChemexpress Co., Ltd.


H2O:34mg/mL by MedChemexpress Co., Ltd.

Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Histamine - Launched

Safety Data of Histamine

Hazard Symbols : Xn
Risk Statements : R22;R36/37/38;R42/43
Safety Statements : S22;S26;S36/37
Transport Information : UN 2811
RTECS : MS1050000
WGKGermany : 3

Spectral Information


Suppliers List

Company Price and Availability Country/Region
ACP Chemicals Inc. USA
AbMole BioScience USA
Abcam 1g/USD96();5g/USD384() USA
Acros Organics 1g/USD74();5g/USD243();25g/USD796() Belgium
Aladdin 1g/RMB323();5g/RMB1259() China
Alfa Chemistry USA
BOC Sciences
BroadPharm 500mg/USD32();1g/USD52() USA
EMD Millipore 1g/USD99();5g/USD339() USA
Fluorochem United Kingdom
MAYA-R 1g/RMB380();5g/RMB1460() China
MedChemexpress Co., Ltd. 100mg/USD60() USA
Pure Chemistry Scientific Inc. 1g/USDnull(In stock) USA
Santa Cruz Biotechnology, Inc. 1g/USD80();5g/USD265() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60() China
Shanghai Yuanju Bio-Tech Co., Ltd. China
Sigma-Aldrich, Inc. 100mg/USD45(analytical standard);1g/USD83();5g/USD272();25g/USD1095() USA
Spectrum Chemical Mfg. Corp. 1g/USD277();5g/USD938();25g/USD2932() USA
Target Molecule Corp. 10mg/USD22();50mg/USD98();100mg/USD178() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 250mg/RMB174();5g/RMB2498() China
Wuhan ChemFaces Biochemical Co., Ltd. 100mg/USD70() China
Xuzhou Xbetop Biotechnology Co., Ltd. China

Related Products

Other Forms of 51-45-6

Name CAS No Formula MW
Histamine dihydrochloride 56-92-8 C5H11Cl2N3 184.07
Histamine phosphate 51-74-1 C5H12N3O4P 209.14

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis



Protocol Reference


More Information


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