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141626-36-0 (Dronedarone)

1

Identification

Dronedarone Dronedarone
Name Dronedarone
Formula C31H44N2O5S
MW 556.76
CAS No. 141626-36-0
EINECS
Smiles O=C(C1=CC=C(OCCCN(CCCC)CCCC)C=C1)C2=C(CCCC)OC(C=C3)=C2C=C3NS(C)(=O)=O
Synonyms N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide; 2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-(methylsulfonamido)benzofuran; N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)methanesulfonamide
InChI InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
2

Introduction

Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF. IC50 value: Target: multichannel blocker

Background Information

Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties. ......by BOC Sciences
A multichannel blocker agent that has antiarrhythmic activity; reduces the late sustained K(+) current, I(K) (or Isus) with EC50 of 0.85 uM in postmyocardial infarcted (PMI) rats; reduces significantly the incidence of ventricular fibrillation (VF) in rats; mainly used for treatment of cardiac arrhythmias.Heart ArrhythmiaApproved ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000028782

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dronedarone Sanofi Atrial fibrillation 2010/10/31 2012/4/30 Phase 4 Clinical
Dronedarone Sanofi Atrial fibrillation 2010/9/30 2012/1/1 Phase 4 Clinical
Dronedarone Sanofi Atrial fibrillation 2010/9/30 2011/12/31 Phase 4 Clinical
Dronedarone Sanofi Atrial fibrillation 2010/7/31 2012/2/29 Phase 4 Clinical
Dronedarone Eastbourne District General Hospital Atrial fibrillation 2010/3/31 2010/3/31 Phase 4 Clinical
Dronedarone - Launched
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Safety Data of Dronedarone

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 141626-36-0

Name CAS No Formula MW
Dronedarone (Hydrochloride) 141625-93-6 C31H45ClN2O5S 593.22

Recommended Compounds in mAChR Autophagy

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
Vernakalant 794466-70-9 C20H31NO4 349.46
Dabigatran etexilate (mesylate) 872728-81-9 C35H45N7O8S 723.84
Colchicine 64-86-8 C22H25NO6 399.44
5-R-Rivaroxaban 865479-71-6 C19H18ClN3O5S 435.88
Vernakalant (Hydrochloride) 748810-28-8 C20H32ClNO4 385.93
Rivaroxaban 366789-02-8 C19H18ClN3O5S 435.88
Edoxaban 480449-70-5 C24H30ClN7O4S 548.06
Edoxaban (tosylate) 480449-71-6 C31H38ClN7O7S2 720.26
Apixaban 503612-47-3 C25H25N5O4 459.5
Amiodarone (hydrochloride) 19774-82-4 C25H30ClI2NO3 681.77
Betrixaban 330942-05-7 C23H22ClN5O3 451.91
Capadenoson 544417-40-5 C25H18ClN5O2S2 520.03
Atorvastatin (hemicalcium salt) 134523-03-8 C66H68CaF2N4O10 1155.34
Dronedarone (Hydrochloride) 141625-93-6 C31H45ClN2O5S 593.22
Dabigatran 211914-51-1 C25H25N7O3 471.51
Dabigatran etexilate 211915-06-9 C34H41N7O5 627.73
VITAMIN K1 12001-79-5 C31H46O2 450.7
Heparin 9005-49-6 C26H42N2O37S5 1134.93
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Route of Synthesis

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References

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More Information

Dronedarone

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