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137234-62-9 (Voriconazole)



Voriconazole Voriconazole
Name Voriconazole
Formula C16H14F3N5O
MW 349.31
CAS No. 137234-62-9
EINECS 200-261-5
Smiles FC1=CC=C([[email protected]@]([[email protected]](C2=NC=NC=C2F)C)(O)CN3N=CN=C3)C(F)=C1
Synonyms 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
InChI InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1


Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections. IC50 Value: Target: Antifungal Voriconazole displays potent activity against Candida, Cryptococcus and Aspergillus species.

Background Information

A triazole antifungal medication that is generally used to treat serious, invasive fungal infections ......by AOBIOUS INC
Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.Voriconazole undergoes extensive hepatic metabolism via the cytochrome P450 enzymes, primarily CYP2C9 and CYP3A4. In addition, voriconazole also causes some side effects, such as visual disturbances, skin rashes and elevations in hepatic enzyme levels. ......by AbMole BioScience
Voriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion. ......by AdooQ BioScience, LLC
Voriconazole has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. ......by BOC Sciences
Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. Voriconazole has also been proven effective against a number of other serious fungal pathogens. This includes infections by Fusarium spp and Scedosporium apiospermum (asexual form of Pseudallescheria boydii). Although infrequently seen, these molds are emerging as more common and deadly causes of fungal infection in seriously immunocompromised patients, and the development of voriconazole has been an important advance in their treatment as they are generally resistant to other antifungal agents (including amphotericin B). Voriconazole is the first and only drug ever specifically indicated for their treatment by the FDA. Voriconazole has also been used to treat severe fungal corneal infection. ......by MedKoo Biosciences, Inc.
A a triazole antifungal agent that acts as a 14α-demethylase inhibitor; used to treat and prevent invasive fungal infections including aspergillosis andcandidiasis and fungal infections caused by Scedosporium and Fusarium species. Fungal infectionApproved ......by ProbeChem
Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. ......by Selleck Chemicals LLC
Voriconazole is an Azole Antifungal. Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. ......by Target Molecule Corp.
Triazole antifungal agent. Displays potent activity against Candida, Cryptococcus and Aspergillus species.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028321

Storage condition

Store at +4°C by Tocris Bioscience Inc.


DMSO 100 mg/ml Ethanol 100 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 70 mg/mL (200.39 mM); Ethanol20 mg/mL (57.25 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol10 mg/mL by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.

Mechanism and Indication


Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Voriconazole Pfizer Inc Scedosporium infection 2006/7/31 2012/5/31 Phase 4 Clinical
Voriconazole Martin-Luther-Universitaet 2009/2/28 2013/8/31 Phase 4 Clinical
Voriconazole Johns Hopkins University Fungal infection 2012/1/31 2014/6/30 Phase 4 Clinical
Voriconazole Pfizer Inc Fungal infection 2006/4/30 2012/5/31 Phase 4 Clinical
Voriconazole University of Colorado System Fungal infection 2010/5/31 2012/11/1 Phase 4 Clinical
Voriconazole - Launched

Safety Data of Voriconazole

Hazard Symbols : Xn,T,F
Risk Statements : 22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
Safety Statements : 26-36-45-36/37-22-53-16

Spectral Information


Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Aagami, Inc. USA
AbMole BioScience USA
Adipogen Corporation USA
AdooQ BioScience, LLC USA
BOC Sciences
Beijing Dezhong Wanquan Medicines Technological Development Co., Ltd. China
Beijing Lunarsun Pharmaceutical Co., Ltd. China
Beijing Mediking Biopharm Co., Ltd. China
Biochempartner Co., Ltd China
Broad Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC 50mg/USD96();100mg/USD125() USA
Cayman Chemical Company USA
Chem-Cook Chemicals Ltd. China
Chengdu Sino-Strong Pharmaceutical Co., Ltd. China
Dalian Wista Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD96();100mg/USD125() USA
MedKoo Biosciences, Inc. USA
Pure Chemistry Scientific Inc. 100mg/USD143(In stock) USA
Selleck Chemicals LLC 10mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);25mg/USD150(In stock);100mg/USD470(In stock);200mg/USD870(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD96();100mg/USD125() China
Target Molecule Corp. 2mg/USD24();10mg/USD86();25mg/USD118() USA
Tocris Bioscience Inc. USA

Related Products

Other Forms of 137234-62-9

Name CAS No Formula MW
4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-, mono[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate] (salt) 137234-71-0 C26H30F3N5O5S 581.61
(2R,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 137330-52-0 C16H14F3N5O 349.31

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Posaconazole 171228-49-2 C37H42F2N8O4 700.78

Route of Synthesis




More Information


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