• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

137234-62-9 (Voriconazole)

1

Identification

Voriconazole Voriconazole
Name Voriconazole
Formula C16H14F3N5O
MW 349.31
CAS No. 137234-62-9
EINECS 200-261-5
Smiles FC1=CC=C([[email protected]@]([[email protected]](C2=NC=NC=C2F)C)(O)CN3N=CN=C3)C(F)=C1
Synonyms 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
InChI InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
2

Introduction

Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections. IC50 Value: Target: Antifungal Voriconazole displays potent activity against Candida, Cryptococcus and Aspergillus species.

Background Information

Voriconazole has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. ......by BOC Sciences
Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. ......by Selleck Chemicals LLC
Voriconazole is an Azole Antifungal. Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. ......by Target Molecule Corp.
Triazole antifungal agent. Displays potent activity against Candida, Cryptococcus and Aspergillus species.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028321

Storage condition

Store at +4°C by Tocris Bioscience Inc.

Solubility

DMSO 100 mg/ml Ethanol 100 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 70 mg/mL (200.39 mM); Ethanol20 mg/mL (57.25 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol10 mg/mL by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Voriconazole Pfizer Inc Scedosporium infection 2006/7/31 2012/5/31 Phase 4 Clinical
Voriconazole Martin-Luther-Universitaet 2009/2/28 2013/8/31 Phase 4 Clinical
Voriconazole Johns Hopkins University Fungal infection 2012/1/31 2014/6/30 Phase 4 Clinical
Voriconazole Pfizer Inc Fungal infection 2006/4/30 2012/5/31 Phase 4 Clinical
Voriconazole University of Colorado System Fungal infection 2010/5/31 2012/11/1 Phase 4 Clinical
Voriconazole - Launched
7

Safety Data of Voriconazole

Hazard Symbols : Xn,T,F
Risk Statements : 22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
Safety Statements : 26-36-45-36/37-22-53-16
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aagami, Inc. USA
BOC Sciences
Beijing Dezhong Wanquan Medicines Technological Development Co., Ltd. China
Beijing Lunarsun Pharmaceutical Co., Ltd. China
Beijing Mediking Biopharm Co., Ltd. China
Biochempartner Co., Ltd China
Broad Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC 50mg/USD96();100mg/USD125() USA
Chem-Cook Chemicals Ltd. China
Chengdu Sino-Strong Pharmaceutical Co., Ltd. China
Dalian Wista Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD96();100mg/USD125() USA
Pure Chemistry Scientific Inc. 100mg/USD143(In stock) USA
Selleck Chemicals LLC 10mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);25mg/USD150(In stock);100mg/USD470(In stock);200mg/USD870(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD96();100mg/USD125() China
Target Molecule Corp. 2mg/USD24();10mg/USD86();25mg/USD118() USA
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 137234-62-9

Name CAS No Formula MW
4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-, mono[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate] (salt) 137234-71-0 C26H30F3N5O5S 581.61
(2R,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 137330-52-0 C16H14F3N5O 349.31

Recommended Compounds in Fungal

Name CAS No Formula MW
Micafungin 235114-32-6 C56H71N9O23S 1270.27
Pneumocandin B0 135575-42-7 C50H80N8O17 1065.21
UM729 1448723-60-1 C20H25N5O2 367.44
Sertaconazole (nitrate) 99592-39-9 C20H16Cl3N3O4S 500.78
Miconazole (nitrate) 22832-87-7 C18H15Cl4N3O4 479.14
Naftifine (hydrochloride) 65473-14-5 C21H22ClN 323.86
Hygromycin B 31282-04-9 C20H37N3O13 527.52
Miconazole 22916-47-8 C18H14Cl4N2O 416.13
Econazole (nitrate) 24169-02-6 C18H16Cl3N3O4 444.7
Ciclopirox 29342-05-0 C12H17NO2 207.27
Methasulfocarb 66952-49-6 C9H11NO4S2 261.32
Flumorph 211867-47-9 C21H22FNO4 371.4
Itraconazole 84625-61-6 C35H38Cl2N8O4 705.63
Tolnaftate 2398-96-1 C19H17NOS 307.41
Fenticonazole (Nitrate) 73151-29-8 C24H21Cl2N3O4S 518.41
Liranaftate 88678-31-3 C18H20N2O2S 328.43
Tioconazole 65899-73-2 C16H13Cl3N2OS 387.71
Bifonazole 60628-96-8 C22H18N2 310.39
Butoconazole (nitrate) 64872-77-1 C19H18Cl3N3O3S 474.79
Amphotericin B 1397-89-3 C47H73NO17 924.08

Recommended Compounds in Same Indication

Name CAS No Formula MW
Posaconazole 171228-49-2 C37H42F2N8O4 700.78
11

Route of Synthesis

12

References

13

More Information

Voriconazole

Tags: buy 137234-62-9 IC50 | 137234-62-9 price | 137234-62-9 cost | 137234-62-9 solubility | 137234-62-9 purchase | 137234-62-9 manufacturer | 137234-62-9 research buy | 137234-62-9 order | 137234-62-9 MSDS | 137234-62-9 chemical structure | 137234-62-9 Storage condition | 137234-62-9 molecular weight | 137234-62-9 mw | 137234-62-9 datasheet | 137234-62-9 supplier | 137234-62-9 cell line | 137234-62-9 NMR | 137234-62-9 MS | 137234-62-9 IR | 137234-62-9 solubility | 137234-62-9 Safe information | 137234-62-9 Qc and Spectral Information | 137234-62-9 Clinical Information | 137234-62-9 Clinical Trial | 137234-62-9 Route of Synthesis | 137234-62-9 storage condition | 137234-62-9 diseases and conditions | 137234-62-9 flash point | 137234-62-9 boiling point | 137234-62-9 melting point | 137234-62-9 storage condition | 137234-62-9 brand