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375345-95-2 (LY451395)

1

Identification

LY451395 LY451395
Name LY451395
Formula C21H30N2O4S2
MW 438.6
CAS No. 375345-95-2
EINECS
Smiles C[[email protected]@H](CNS(C(C)C)(=O)=O)C1=CC=C(C2=CC=C(CCNS(C)(=O)=O)C=C2)C=C1
Synonyms Mibampator;LY 451395;LY-451395; (R)-N-(2-(4'-(2-(methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
InChI InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1
2

Introduction

LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors. IC50 value: Target: AMPA receptor potentiator in vitro: in vivo: Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1].

Background Information

Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species. LY404187 and LY451395 reverses the central effects of an acutely in ......by BOC Sciences
Mibampator, also known as LY-451395, is an AMPA receptor potentiator under development for agitation/aggression in Alzheimer's disease. Patients treated with LY451395 did not show a statistically significant separation from patients taking placebo on the Alzheimer's Disease Assessment Scale-Cognitive Subscale, the primary outcome measure. ......by MedKoo Biosciences, Inc.
A potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors. ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000023923

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LY451395 Eli Lilly and Company Alzheimer's Disease 2009/2/12 Phase 2 Clinical
LY451395 Eli Lilly and Company Alzheimer's Disease 2003/1/17 Phase 2 Clinical
LY451395 - Phase 2
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Safety Data of LY451395

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD420();10mg/USD600() USA
MedChemexpress Co., Ltd. 5mg/USD420();10mg/USD600() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD420();10mg/USD600() China
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Related Products

Other Forms of 375345-95-2

Name CAS No Formula MW

Recommended Compounds in iGluR

Name CAS No Formula MW
PEAQX 459836-30-7 C17H17BrN3O5P 454.2117
Dextromethorphan (hydrobromide) 125-69-9 C18H26BrNO 352.31
Piracetam 7491-74-9 C6H10N2O2 142.16
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Coluracetam 135463-81-9 C19H23N3O3 341.4
NMDA 6384-92-5 C5H9NO4 147.13
Sunifiram 314728-85-3 C14H18N2O2 246.3
SDZ 220-581 (hydrochloride) 179411-93-9 C16H18Cl2NO5P 406.2
Orphenadrine (citrate) 4682-36-4 C24H31NO8 461.5
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Ro 25-6981 (Maleate) 1312991-76-6 C26H33NO6 455.54
Ro 25-6981 169274-78-6 C22H29NO2 339.47
Felbamate (hydrate) 1177501-39-1 C11H16N2O5 256.26
Felbamate 25451-15-4 C11H14N2O4 238.24
Flupirtine 56995-20-1 C15H17FN4O2 304.32
Noopept 157115-85-0 C17H22N2O4 318.37
QNZ46 1237744-13-6 C24H17N3O6 443.4083
SDZ 220-581 (Ammonium salt) 179411-94-0 C16H20ClN2O5P 386.77
MDL-29951 130798-51-5 C12H9Cl2NO4 302.11
MDL 105519 161230-88-2 C18H11Cl2NO4 376.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
CHF5074 749269-83-8 C16H11Cl2FO2 325.1617
Azeliragon 603148-36-3 C32H38ClN3O2 532.116
MSDC 0160 146062-49-9 C19H18N2O4S 370.42
THK5351 1707147-26-9 C18H18FN3O2 0.0
MK-0249 862309-06-6 C23H24F3N3O2 431.45
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Route of Synthesis

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References

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More Information

LY451395

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