• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

23541-50-6 (Daunorubicin (Hydrochloride))

1

Identification

Daunorubicin (Hydrochloride) Daunorubicin (Hydrochloride)
Name Daunorubicin (Hydrochloride)
Formula C27H30ClNO10
MW 563.98
CAS No. 23541-50-6
EINECS 245-723-4
Smiles O=C(C(C(OC)=CC=C1)=C1C2=O)C3=C2C(O)=C(C[[email protected]@](O)(C(C)=O)C[[email protected]@H]4O[[email protected]@]5([H])C[[email protected]](N)[[email protected]](O)[[email protected]](C)O5)C4=C3O.[H]Cl
Synonyms RP 13057 Hydrochloride;Daunomycin;RP13057 Hydrochloride;RP-13057 Hydrochloride;Rubidomycin hydrochloride; (8S,10S)-8-acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
InChI InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
2

Introduction

Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

Background Information

Antineoplastic antibiotic, inhibiting DNA replication and repair and RNA and protein synthesis ......by AOBIOUS INC
Daunorubicin hydrochloride inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. ......by AbMole BioScience

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

......by AdooQ BioScience, LLC
Daunorubicin hydrochloride is a topoisomerase II inhibitor. ......by MedChemexpress Co., Ltd.
Daunorubicin hydrochloride is the hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. ......by MedKoo Biosciences, Inc.
Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells; Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).Chemotherapeutic AgentsApproved ......by ProbeChem
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. ......by Selleck Chemicals LLC
Daunorubicin is an anthracycline antibiotic. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia. Daunorubicin can affect the metabolism and synthesis of DNA and RNA. In the in vitro assay, daunorubicin inhibits the incorporation of thymidine and uridine into L1210 cells. It also inhibits the incorporation of labeled precursors into the isolated DNA and RNA from incubated cells. When treated with leukemic cells isolated from acute lymphocytic leukemia patients, daunorubicin significantly inhibits the biosynthesis of the DNA and RNA macromolecules ......by Target Molecule Corp.
Anticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Pink to red Solid EBNumber:EB000023553

Storage condition

Solubility

DMSO 113 mg/mL ;Water 113mg/mL; Ethanol 13 mg/mL by MedChemexpress Co., Ltd.
DMSO 113 mg/mL (200 mM) ; Water 113 mg/mL (200 mM) ; Ethanol 13 mg/mL (23 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Daunorubicin (Hydrochloride) PETHEMA Foundation Acute lymphoblastic leukemia 2000/1/31 2005/4/30 Phase 4 Clinical
Daunorubicin (Hydrochloride) Johann Wolfgang Goethe-Universitat Frankfurt am Main Acute lymphoblastic leukemia 1999/10/31 Phase 4 Clinical
Daunorubicin (Hydrochloride) Technische Universitat Dresden Acute myelogenous leukemia 2005/1/31 2010/7/31 Phase 4 Clinical
Daunorubicin (Hydrochloride) Johann Wolfgang Goethe-Universitat Frankfurt am Main Adult T-cell lymphoma 2004/4/30 2009/3/1 Phase 4 Clinical
Daunorubicin (Hydrochloride) Johann Wolfgang Goethe-Universitat Frankfurt am Main Acute lymphoblastic leukemia 2003/4/30 Phase 4 Clinical
Daunorubicin (Hydrochloride) - Launched
7

Safety Data of Daunorubicin (Hydrochloride)

Hazard Symbols : Xn,Xi
Risk Statements : 22-40-42/43-36/37/38-20/21/22
Safety Statements : 22-36/37-45-37/39-36-26
RTECS : HB7878000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Huafeng United Technology Co., Ltd. China
BioVision, Inc., 10mg/USD79() USA
Biochempartner Co., Ltd China
Bridge Bioservice LLC USA
CHEMSCENE, LLC 10mg/USD72();50mg/USD180() USA
Carbosynth Limited 100mg/USD50()
Cayman Chemical Company 5mg/USD39() USA
EMD Millipore 5mg/USD69() USA
Matrix Scientific 250mg/USD167() USA
Maxchemco Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD72();50mg/USD180() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Santa Cruz Biotechnology, Inc. 10mg/USD96() USA
Selleck Chemicals LLC 10mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);50mg/USD270(In stock) USA
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD72();50mg/USD180() China
Sigma-Aldrich, Inc. 1mg/USD45() USA
Target Molecule Corp. 2mg/USD24();10mg/USD62();50mg/USD153() USA
Tocris Bioscience Inc. 10mg/USD139() USA
Tokyo Chemical Industry Co., Ltd. 20mg/USD165() Japan
Toronto Research Chemicals Inc. 5mg/USD50() Canada
Zhangjiagang Sunrise Fine Chemical Co., Ltd. China
10

Related Products

Other Forms of 23541-50-6

Name CAS No Formula MW
Daunorubicin 20830-81-3 C27H29NO10 527.52

Recommended Compounds in Topoisomerase ADC Cytotoxin Autophagy

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Exatecan (Mesylate) 169869-90-3 C25H26FN3O7S 531.55
Flumequine 42835-25-6 C14H12FNO3 261.25
Nemorubicin 108852-90-0 C32H37NO13 643.64
Amsacrine (hydrochloride) 54301-15-4 C21H20ClN3O3S 429.92
Ellipticine 519-23-3 C17H14N2 246.31
DOXO-EMCH 151038-96-9 C37H42N4O13 750.75
Topotecan (Hydrochloride) 119413-54-6 C23H24ClN3O5 457.91
Topotecan 123948-87-8 C23H23N3O5 421.45
Tirapazamine 27314-97-2 C7H6N4O2 178.15
Teniposide 29767-20-2 C32H32O13S 656.65
TAS-103 174634-08-3 C20H19N3O2 333.38
TAS-103 (dihydrochloride) 174634-09-4 C20H21Cl2N3O2 406.31
Pixantrone (dimaleate) 144675-97-8 C21H23N5O6 441.44
Pixantrone 144510-96-3 C17H19N5O2 325.37
Pirarubicin 72496-41-4 C32H37NO12 627.64
SN-38 86639-52-3 C22H20N2O5 392.4
Irinotecan (hydrochloride) 100286-90-6 C33H39ClN4O6 623.14
Exatecan 171335-80-1 C24H22FN3O4 435.45
Etoposide 33419-42-0 C29H32O13 588.56

Recommended Compounds in Same Indication

Name CAS No Formula MW
AZD1152 722543-31-9 C26H31FN7O6P 587.54
AZD1152-HQPA 722544-51-6 C26H30FN7O3 507.56
Mocetinostat 726169-73-9 C23H20N6O 396.44
Volasertib 755038-65-4 C34H50N8O3 618.81
KX2-391 897016-82-9 C26H29N3O3 431.53
MLN4924 905579-51-3 C21H25N5O4S 443.52
Dexamethasone 50-02-2 C22H29FO5 392.46
Nordihydroguaiaretic acid 500-38-9 C18H22O4 302.36
Cyclophosphamide 50-18-0 C7H15Cl2N2O2P 261.09
Crenolanib 670220-88-9 C26H29N5O2 443.54
Imatinib (hydrochloride) 862366-25-4 C29H32ClN7O 530.06
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 420.48
ARRY-520 885060-09-3 C20H22F2N4O2S 420.48
Imatinib (Mesylate) 220127-57-1 C30H35N7O4S 589.71
6-Mercaptopurine 50-44-2 C5H4N4S 152.18
LY2090314 603288-22-8 C28H25FN6O3 512.53
Posaconazole 171228-49-2 C37H42F2N8O4 700.78
Decitabine 2353-33-5 C8H12N4O4 228.21
5-Azacytidine 320-67-2 C8H12N4O5 244.2
2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one C21H20ClNO5 401.8402
11

Route of Synthesis

12

References

13

More Information

Daunorubicin (Hydrochloride)

Tags: buy 23541-50-6 IC50 | 23541-50-6 price | 23541-50-6 cost | 23541-50-6 solubility | 23541-50-6 purchase | 23541-50-6 manufacturer | 23541-50-6 research buy | 23541-50-6 order | 23541-50-6 MSDS | 23541-50-6 chemical structure | 23541-50-6 Storage condition | 23541-50-6 molecular weight | 23541-50-6 mw | 23541-50-6 datasheet | 23541-50-6 supplier | 23541-50-6 cell line | 23541-50-6 NMR | 23541-50-6 MS | 23541-50-6 IR | 23541-50-6 solubility | 23541-50-6 Safe information | 23541-50-6 Qc and Spectral Information | 23541-50-6 Clinical Information | 23541-50-6 Clinical Trial | 23541-50-6 Route of Synthesis | 23541-50-6 storage condition | 23541-50-6 diseases and conditions | 23541-50-6 flash point | 23541-50-6 boiling point | 23541-50-6 melting point | 23541-50-6 storage condition | 23541-50-6 brand