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103-90-2 (Acetaminophen)

1

Identification

Acetaminophen Acetaminophen
Name Acetaminophen
Formula C8H9NO2
MW 151.16
CAS No. 103-90-2
EINECS 203-157-5
Smiles CC(NC1=CC=C(O)C=C1)=O
Synonyms p-Hydroxyacetanilide; Acetaminophen; Paracetamol; N-Acetyl-4-aminophenol; APAP; N-(4-hydroxyphenyl)acetamide
InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
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Introduction

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor. Target: COX-2 Acetaminophen acts functionally as a selective COX-2 inhibitor led us to investigate the hypothesis of whether it works via preferential COX-2 blockade.

Background Information

Acetaminophen is a highly selective inhibitor of COX-2 and 6-keto-PGF1 alpha with IC50 of 302.3 mg/kg and 10 uM, respectively. Administration of high-dose AAP [302.3 mg/kg (IC50 for COX-2)] or PHE [179.2 mg/kg (IC50 for COX-2)] and of non-specific (indomethacin: 20 mg/kg) or specific COX-2 (NS-398: 10 mg/kg) inhibitor impaired the performance in hidden platform (HP) not visible platform (VP) tasks, whereas low-dose (15.1 mg/kg) AAP facilitated performance in HP and VP tasks. Nanomolar concentrations of peroxynitrite increased the activity of isolated PGHS and prostacyclin formation by aortic endothelial cells. This elevated activity was efficiently inhibited by pharmacologically relevant concentrations of acetaminophen (IC50 approximately 10 uM for 6-keto-PGF1alpha) and other free radical scavengers. </ ......by AbMole BioScience
A selective COX-2 inhibitor ......by BOC Sciences
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. ......by MedChemexpress Co., Ltd.
Paracetamol is also known as Acetaminophen. Paracetamol is Widely used analgesic and antipyretic agent for mild-to-moderate pain and fever. it is a selective cyclooxygenase-2 inhibitor. Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. ......by MedKoo Biosciences, Inc.
Acetaminophen is an analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. ......by MedKoo Biosciences, Inc.
A well-known analgesic and antipyretic agent that selectively inhibits COX activities in the brain; might modulate the endogenous cannabinoid system in the brain through paracetamol's metabolite, AM404; is typically used for mild to moderate pain.PainApproved ......by ProbeChem
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. ......by Target Molecule Corp.
Cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000020213

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Acetaminophen - Launched
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Safety Data of Acetaminophen

Hazard Symbols : Xn
Risk Statements : R22;R36/38;R52/53
Safety Statements : S26;S37/39;S61
HS Code : 29242930
RTECS : AE4200000
WGKGermany : 1
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 103-90-2

Name CAS No Formula MW
4-Acetamidophenyl acetate 2623-33-8 C10H11NO3 193.2

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

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References

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More Information

Acetaminophen

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