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947257-66-1 (D-3263)

1

Identification

D-3263 D-3263
Name D-3263
Formula C21H31N3O3
MW 373.49
CAS No. 947257-66-1
EINECS
Smiles O=C1N(CCN)C2=CC(OC)=CC=C2N1C([[email protected]]3[[email protected]](C(C)C)CC[[email protected]@H](C)C3)=O
Synonyms 3-(2-aminoethyl)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarbonyl)-5-methoxy-1H-benzo[d]imidazol-2(3H)-one
InChI InChI=1S/C21H31N3O3/c1-13(2)16-7-5-14(3)11-17(16)20(25)24-18-8-6-15(27-4)12-19(18)23(10-9-22)21(24)26/h6,8,12-14,16-17H,5,7,9-11,22H2,1-4H3/t14-,16+,17-/m1/s1
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Introduction

D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.

Background Information

D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase ......by BOC Sciences
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. ......by MedChemexpress Co., Ltd.
D-3263 is a TRPM8 agonist ( transient receptor potential melastatin member 8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. ......by MedKoo Biosciences, Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000018820

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target TRP Channel
Research Area
Indications Solid Tumors
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
D-3263 Dendreon Solid Tumors 2009/3/1 Phase 1
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Safety Data of D-3263

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 1mg/USD768();5mg/USD1536() USA
MedChemexpress Co., Ltd. 1mg/USD768();5mg/USD1536() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1mg/USD768();5mg/USD1536() China
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Related Products

Other Forms of 947257-66-1

Name CAS No Formula MW
D-3263 (hydrochloride) 1008763-54-9 C21H32ClN3O3 409.9501
D-3263 (Trifluoroacetate) 947257-67-2 C23H32F3N3O5 487.51

Recommended Compounds in TRP Channel

Name CAS No Formula MW
SN 2 823218-99-1 C17H21NO 255.35
SB 366791 472981-92-3 C16H14ClNO2 287.74
Nonivamide 2444-46-4 C17H27NO3 293.4
Tramadol (hydrochloride) 36282-47-0 C16H26ClNO2 299.84
Probenecid 57-66-9 C13H19NO4S 285.36
SAR7334 (hydrochloride) 1333207-63-8 C21H24Cl3N3O 440.79376
Imperatorin 482-44-0 C16H14O4 270.28
SAR7334 1333210-07-3 C21H22ClN3O 367.87188
Capsazepine 138977-28-3 C19H21ClN2O2S 376.9
Mifamurtide 83461-56-7 C59H109N6O19P 1237.5
Rosiglitazone 122320-73-4 C18H19N3O3S 357.43
D-3263 (hydrochloride) 1008763-54-9 C21H32ClN3O3 409.9501
Chembridge-5861528 332117-28-9 C19H23N5O3 369.4176
HC-030031 349085-38-7 C18H21N5O3 355.39
ABT-239 460746-46-7 C22H22N2O 330.4229
Icilin 36945-98-9 C16H13N3O4 311.29
AMG 517 659730-32-2 C20H13F3N4O2S 430.4
SB-705498 501951-42-4 C17H16BrF3N4O 429.23
Capsaicin 404-86-4 C18H27NO3 305.41
SKF-96365 (hydrochloride) 130495-35-1 C22H27ClN2O3 402.9144

Recommended Compounds in Same Indication

Name CAS No Formula MW
MSX-122 897657-95-3 C16H16N6 292.34
NKP-1339 197723-00-5 C14H12Cl4N4NaRu 502.14
NLG-919 1402836-58-1
Gemcitabine (elaidate) 210829-30-4 C27H43F2N3O5 527.6442
Oprozomib 935888-69-0 C25H32N4O7S 532.61
VITAMIN K1 12001-79-5 C31H46O2 450.7
GLPG0187 1320346-97-1 C29H37N7O5S 595.71
BGB-283 1446090-77-2 C25H17F3N4O3 478.42
Lurbinectedin 497871-47-3 C41H44N4O10S 784.87
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Route of Synthesis

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References

Protocol Reference

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More Information

D-3263

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