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1095173-27-5 (PF-04449913)

1

Identification

PF-04449913 PF-04449913
Name PF-04449913
Formula C21H22N6O
MW 374.44
CAS No. 1095173-27-5
EINECS
Smiles O=C(NC1=CC=C(C#N)C=C1)N[[email protected]]2C[[email protected]](C3=NC4=CC=CC=C4N3)N(C)CC2
Synonyms PF04449913;PF 04449913; 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
InChI InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
2

Introduction

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor. IC50 value: 5 nM [1] Target: smoothened PF-04449913, a Smoothened inhibitor was identified possessing excellent potency and physical properties that translate to an attractive predicted human pharmacokinetic profile.

Background Information

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened. ......by AdooQ BioScience, LLC
Glasdegib, als known as PF-04449913, is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling ......by BOC Sciences
PF-04449913 is a potent and orally bioavailable smoothened inhibitor. PF-04449913 binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. ......by MedChemexpress Co., Ltd.
Glasdegib, also known as PF-04449913, is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. ......by MedKoo Biosciences, Inc.
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. ......by Selleck Chemicals LLC
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018604

Storage condition

Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PF-04449913 H Lee Moffitt Cancer Center and Research Institute Myelodysplastic syndrome 2013/9/30 2014/12/31 Phase 2 Clinical
PF-04449913 University of Colorado at Denver and Health Sciences Center Acute myelogenous leukemia 2013/4/30 2019/4/30 Phase 2 Clinical
PF-04449913 Pfizer Inc Acute myelogenous leukemia; Myelodysplastic syndrome 2012/7/31 2015/4/30 Phase 1/Phase 2 Clinical
PF-04449913 Pfizer Inc Hematological neoplasm 2010/3/31 2013/2/1 Phase 1a Clinical
PF-04449913 Pfizer Inc 2014/5/31 2014/7/31 Phase 1 Clinical
PF-04449913 Pfizer Inc Acute myelogenous leukemia; Hematological neoplasm; Myelodysplastic syndrome 2014/3/31 2016/6/30 Phase 1 Clinical
PF-04449913 - Phase 2
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Safety Data of PF-04449913

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 5mg/USD90() USA
Affix Scientific 10mg/USD400() USA
Apexbio Technology LLC 5mg/USD103(In Stock) USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD300();50mg/USD900() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 10mg/USD300();50mg/USD900() USA
MedKoo Biosciences, Inc. 1mg/USD80() USA
Selleck Chemicals LLC 5mg/USD147(In Stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD300();50mg/USD900() China
Target Molecule Corp. 10mg/USD153();100mg/USD988() USA
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Related Products

Other Forms of 1095173-27-5

Name CAS No Formula MW

Recommended Compounds in Smo

Name CAS No Formula MW
Jervine 469-59-0 C27H39NO3 425.6
BMS-833923 1059734-66-5 C30H27N5O 473.57
PF-5274857 1373615-35-0 C20H25ClN4O3S 436.96
LDE225 (Diphosphate) 1218778-77-8 C26H32F3N3O11P2 681.49
Purmorphamine 483367-10-8 C31H32N6O2 520.62
LDE225 956697-53-3 C26H26F3N3O3 485.5
LY2940680 1258861-20-9 C26H24F4N6O 512.5
Halcinonide 3093-35-4 C24H32ClFO5 454.96
SAG 912545-86-9 C28H28ClN3OS 490.06
MK-4101 935273-79-3 C24H24F5N5O 493.47
MK-5710 1211400-87-1 C26H26N6O3 470.52
ST-8115 C25H26ClN4O4 481.95
ST-8117 C30H28ClN4O4 544.02
ST-8116 C32H32ClN4O4 572.07
ST-8113 C25H25N3O4S 463.55

Recommended Compounds in Same Indication

Name CAS No Formula MW
AZD1152 722543-31-9 C26H31FN7O6P 587.54
AZD1152-HQPA 722544-51-6 C26H30FN7O3 507.56
Mocetinostat 726169-73-9 C23H20N6O 396.44
Volasertib 755038-65-4 C34H50N8O3 618.81
KX2-391 897016-82-9 C26H29N3O3 431.53
MLN4924 905579-51-3 C21H25N5O4S 443.52
SNX-2112 908112-43-6 C23H27F3N4O3 464.48
IDO5L 914471-09-3 C9H7ClFN5O2 271.6356
Panobinostat 404950-80-7 C21H23N3O2 349.43
Rigosertib 592542-59-1 C21H25NO8S 451.49
ON-019190 (sodium) 1225497-78-8 C21H24NNaO8S 473.4719
Crenolanib 670220-88-9 C26H29N5O2 443.54
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 420.48
ARRY-520 885060-09-3 C20H22F2N4O2S 420.48
LY2090314 603288-22-8 C28H25FN6O3 512.53
MEK162 606143-89-9 C17H15BrF2N4O3 441.23
Ezatiostat 168682-53-9 C27H35N3O6S 529.65
Posaconazole 171228-49-2 C37H42F2N8O4 700.78
5-Azacytidine 320-67-2 C8H12N4O5 244.2
Decitabine 2353-33-5 C8H12N4O4 228.21
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Route of Synthesis

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References

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More Information

PF-04449913

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