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104632-25-9 (Pramipexole (dihydrochloride))

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Identification

Pramipexole (dihydrochloride) Pramipexole (dihydrochloride)
Name Pramipexole (dihydrochloride)
Formula C10H19Cl2N3S
MW 284.25
CAS No. 104632-25-9
EINECS
Smiles NC(S1)=NC2=C1C[[email protected]@H](NCCC)CC2.[H]Cl.[H]Cl
Synonyms (S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
InChI InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
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Introduction

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Background Information

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. ......by AbMole BioScience
Pramipexole dihydrochloride is a dopamine receptor agonist exhibiting selectivity for the D3 receptor. ......by AdooQ BioScience, LLC
Pramipexole Dihydrochloride is an agonist of the Gαi-linked dopamine receptors D2, D3, and D4. It is relatively inactive at the Gαs-linked dopamine receptors D1 and D5, as well as at serotonin and adrenergic receptors. This narrow profile of receptor binding distinguishes pramipexole from other compounds, particularly those derived from ergot fungi, which can be associated with adverse events when used for treating Parkinson’s disease and other disorders. ......by MedKoo Biosciences, Inc.
A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).Parkinson's DiseaseApproved ......by ProbeChem
Pramipexole dihydrochloride is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor. ......by Selleck Chemicals LLC
Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018143

Storage condition

Solubility

Water >20 mg/mL DMSO >80 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pramipexole (dihydrochloride) Sandoz Dongkook Ltd Parkinsons disease 2012/2/29 2013/6/30 Phase 4 Clinical
Pramipexole (dihydrochloride) Seoul National University Hospital Parkinsons disease 2011/9/30 2012/10/31 Phase 4 Clinical
Pramipexole (dihydrochloride) Boehringer Ingelheim Corp Parkinsons disease 2011/5/31 2012/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) Boehringer Ingelheim Corp Restless legs syndrome 2007/12/31 2011/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) Stanford University Depression 2010/2/28 2013/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) - Launched
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Safety Data of Pramipexole (dihydrochloride)

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 104632-25-9

Name CAS No Formula MW
Pramipexole 104632-26-0 C10H17N3S 211.33
Dexpramipexole (dihydrochloride) 104632-27-1 C10H19Cl2N3S 284.25
Dexpramipexole 104632-28-2 C10H17N3S 211.33

Recommended Compounds in Dopamine Receptor Autophagy

Name CAS No Formula MW
SKF 38393 (hydrobromide) 20012-10-6 C16H18BrNO2 336.22
Ropinirole (hydrochloride) 91374-20-8 C16H25ClN2O 296.84
Fenoldopam 67227-56-9 C16H16ClNO3 305.76
Pergolide (mesylate) 66104-23-2 C20H30N2O3S2 410.59
Trifluoperazine (dihydrochloride) 440-17-5 C21H26Cl2F3N3S 480.42
Clomipramine (hydrochloride) 17321-77-6 C19H24Cl2N2 351.31
Dopamine (hydrochloride) 62-31-7 C8H12ClNO2 189.64
Domperidone 57808-66-9 C22H24ClN5O2 425.91
Pramipexole 104632-26-0 C10H17N3S 211.33
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Chlorprothixene 113-59-7 C18H18ClNS 315.86
Haloperidol (hydrochloride) 1511-16-6 C21H24Cl2FNO2 412.33
Risperidone (mesylate) 666179-96-0 C24H31FN4O5S 506.59
Risperidone (hydrochloride) 666179-74-4 C23H28ClFN4O2 446.95
Iloperidone (hydrochloride) 1299470-39-5 C24H28ClFN2O4 462.94
Ziprasidone 146939-27-7 C21H21ClN4OS 412.9356
Brexpiprazole 913611-97-9 C25H27N3O2S 433.57
Amisulpride (hydrochloride) 81342-13-4 C17H28ClN3O4S 405.94
L-DOPA 59-92-7 C9H11NO4 197.19
Cariprazine (hydrochloride) 1083076-69-0 C21H33Cl3N4O 463.87

Recommended Compounds in Same Indication

Name CAS No Formula MW
Iloperidone 133454-47-4 C24H27FN2O4 426.48
Tianeptine 72797-41-2 C21H25ClN2O4S 436.95
Tozadenant 870070-55-6 C19H26N4O4S 406.5
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
Asenapine 65576-45-6 C17H16ClNO 285.77
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
Vortioxetine 508233-74-7 C18H22N2S 298.45
Rolipram 61413-54-5 C16H21NO3 275.34
Zolpidem 82626-48-0 C19H21N3O 307.39
Preladenant 377727-87-2 C25H29N9O3 503.56
Curcumin 458-37-7 C21H20O6 368.38
Agomelatine 138112-76-2 C15H17NO2 243.3
NSI-189 1270138-40-3 C22H30N4O 366.5
Rivastigmine (tartrate) 129101-54-8 C18H28N2O8 400.42
Safinamide 133865-89-1 C17H19FN2O2 302.34
Tianeptine (sodium salt) 30123-17-2 C21H24ClN2NaO4S 458.93
Istradefylline 155270-99-8 C20H24N4O4 384.43
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.99
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.9858
Quetiapine (fumarate) 111974-72-2 C46H54N6O8S2 883.09
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Route of Synthesis

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References

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More Information

Pramipexole (dihydrochloride)

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