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104632-25-9 (Pramipexole (dihydrochloride))

1

Identification

Pramipexole (dihydrochloride) Pramipexole (dihydrochloride)
Name Pramipexole (dihydrochloride)
Formula C10H19Cl2N3S
MW 284.25
CAS No. 104632-25-9
EINECS
Smiles NC(S1)=NC2=C1C[[email protected]@H](NCCC)CC2.[H]Cl.[H]Cl
Synonyms (S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
InChI InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
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Introduction

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018143

Storage condition

Solubility

Water >20 mg/mL DMSO >80 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pramipexole (dihydrochloride) Sandoz Dongkook Ltd Parkinsons disease 2012/2/29 2013/6/30 Phase 4 Clinical
Pramipexole (dihydrochloride) Seoul National University Hospital Parkinsons disease 2011/9/30 2012/10/31 Phase 4 Clinical
Pramipexole (dihydrochloride) Boehringer Ingelheim Corp Parkinsons disease 2011/5/31 2012/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) Boehringer Ingelheim Corp Restless legs syndrome 2007/12/31 2011/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) Stanford University Depression 2010/2/28 2013/2/1 Phase 4 Clinical
Pramipexole (dihydrochloride) - Launched
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Safety Data of Pramipexole (dihydrochloride)

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 104632-25-9

Name CAS No Formula MW
Pramipexole 104632-26-0 C10H17N3S 211.33
Dexpramipexole (dihydrochloride) 104632-27-1 C10H19Cl2N3S 284.25
Dexpramipexole 104632-28-2 C10H17N3S 211.33

Recommended Compounds in Dopamine Receptor Autophagy

Name CAS No Formula MW
SKF 38393 (hydrobromide) 20012-10-6 C16H18BrNO2 336.22
Ropinirole (hydrochloride) 91374-20-8 C16H25ClN2O 296.84
Fenoldopam 67227-56-9 C16H16ClNO3 305.76
Pergolide (mesylate) 66104-23-2 C20H30N2O3S2 410.59
Trifluoperazine (dihydrochloride) 440-17-5 C21H26Cl2F3N3S 480.42
Clomipramine (hydrochloride) 17321-77-6 C19H24Cl2N2 351.31
Dopamine (hydrochloride) 62-31-7 C8H12ClNO2 189.64
Domperidone 57808-66-9 C22H24ClN5O2 425.91
Pramipexole 104632-26-0 C10H17N3S 211.33
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Chlorprothixene 113-59-7 C18H18ClNS 315.86
Haloperidol (hydrochloride) 1511-16-6 C21H24Cl2FNO2 412.33
Risperidone (mesylate) 666179-96-0 C24H31FN4O5S 506.59
Risperidone (hydrochloride) 666179-74-4 C23H28ClFN4O2 446.95
Iloperidone (hydrochloride) 1299470-39-5 C24H28ClFN2O4 462.94
Ziprasidone 146939-27-7 C21H21ClN4OS 412.9356
Brexpiprazole 913611-97-9 C25H27N3O2S 433.57
Amisulpride (hydrochloride) 81342-13-4 C17H28ClN3O4S 405.94
L-DOPA 59-92-7 C9H11NO4 197.19
Cariprazine (hydrochloride) 1083076-69-0 C21H33Cl3N4O 463.87

Recommended Compounds in Same Indication

Name CAS No Formula MW
Iloperidone 133454-47-4 C24H27FN2O4 426.48
Tianeptine 72797-41-2 C21H25ClN2O4S 436.95
Tozadenant 870070-55-6 C19H26N4O4S 406.5
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
Asenapine 65576-45-6 C17H16ClNO 285.77
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
Vortioxetine 508233-74-7 C18H22N2S 298.45
Rolipram 61413-54-5 C16H21NO3 275.34
Zolpidem 82626-48-0 C19H21N3O 307.39
Preladenant 377727-87-2 C25H29N9O3 503.56
Curcumin 458-37-7 C21H20O6 368.38
Agomelatine 138112-76-2 C15H17NO2 243.3
NSI-189 1270138-40-3 C22H30N4O 366.5
Rivastigmine (tartrate) 129101-54-8 C18H28N2O8 400.42
Safinamide 133865-89-1 C17H19FN2O2 302.34
Tianeptine (sodium salt) 30123-17-2 C21H24ClN2NaO4S 458.93
Istradefylline 155270-99-8 C20H24N4O4 384.43
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.99
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.9858
Quetiapine (fumarate) 111974-72-2 C46H54N6O8S2 883.09
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Route of Synthesis

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References

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More Information

Pramipexole (dihydrochloride)

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