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51-34-3 (Scopolamine)

1

Identification

Scopolamine Scopolamine
Name Scopolamine
Formula C17H21NO4
MW 303.35
CAS No. 51-34-3
EINECS 200-090-3
Smiles CN1C2CC(CC1C3C2O3)OC(C(C4=CC=CC=C4)CO)=O
Synonyms 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-alpha-(hydroxymethyl)benzeneacetate; 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 3-hydroxy-2-phenylpropanoate
InChI InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3
2

Introduction

Background Information

Scopolamine isolated from the herbs of Atropa belladonna L. ......by BOC Sciences
Scopolamine is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000013605

Storage condition

Solubility

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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Scopolamine Mahidol University|Siriraj Hospital Infertility 2009/1/1
Scopolamine Kocaeli University Abdominal Cramps 2015/7/1 Phase 4
Scopolamine Sisli Etfal Training & Research Hospital Labor Fast 2012/5/1 Phase 4
Scopolamine University Hospital of the West Indies Labor Stage, First 2005/6/1 Phase 2
Scopolamine Valduce Hospital Colonic Adenomas 2012/1/1 Phase 4
Scopolamine Assiut University Pain Relief With HSG 2016/3/1 Phase 4
Scopolamine Changhai Hospital ERCP|Pancreatic Diseases|Bile Duct Diseases 2008/8/1 Phase 3
Scopolamine Cairo University Vaginal Delivery 2017/2/11 Phase 4
Scopolamine Boehringer Ingelheim Healthy 2015/10/1 Phase 1
Scopolamine Mashhad University of Medical Sciences Labor Pain 2010/8/1 Phase 2|Phase 3
Scopolamine Assiut University Endoscopy 2016/9/1 Phase 2|Phase 3
Scopolamine Ain Shams University|Armed Forces Hospitals, Southern Region, Saudi Arabia Prolonged Labor 2014/2/1 Phase 3
Scopolamine Ain Shams Maternity Hospital Analgesia, Obstetrical 2015/9/1 Phase 2
Scopolamine Ahmed Maged|Cairo University Vaginal Delivery 2016/7/1 Phase 4
Scopolamine Lawson Health Research Institute Abdomen, Acute|Children 2017/3/20 Phase 3
Scopolamine Boehringer Ingelheim Healthy 2012/11/1 Phase 1
Scopolamine Hospital Clinic of Barcelona Labor, First Stage 2014/4/1 Phase 4
Scopolamine Boehringer Ingelheim Colic 2006/4/1 Phase 2
Scopolamine Boehringer Ingelheim Abdominal Pain 2008/11/1 Phase 3
Scopolamine Boehringer Ingelheim Healthy 2007/5/1 Phase 1
Scopolamine Mersey Care NHS Trust|University of Manchester|University of Central Lancashire|Manchester Mental Health & Social Care Trust|Lancashire Care NHS Foundation Trust Sialorrhea 2016/2/1 Phase 1|Phase 2
Scopolamine Assiut University Pain Relief 2016/4/1 Phase 2
Scopolamine Boehringer Ingelheim Intestinal Diseases 2013/8/1 Phase 3
Scopolamine Woman's Health University Hospital, Egypt Labor 2015/10/1 Phase 2
Scopolamine Assiut University Family Planning 2016/3/1 Phase 4
Scopolamine Chulalongkorn University Dyspepsia|Emergency|Pain 2011/1/1 Phase 4
Scopolamine Boehringer Ingelheim Acute Pain|Dysmenorrhea 2016/9/1
Scopolamine Capital Medical University Major Depressive Disorder 2017/2/1 Phase 4
Scopolamine Mentis Cura|Landspitali University Hospital AD 2004/4/1
Scopolamine Rutgers, The State University of New Jersey Nausea|Vomiting|Satisfaction 2016/5/1 Phase 4
Scopolamine Drexel University|Merck Sharp & Dohme Corp. Nausea|Vomiting 2008/2/1
Scopolamine Massachusetts General Hospital Depression 2010/4/1 Phase 2
Scopolamine Boston University|Centers for Disease Control and Prevention Motion Sickness 2005/4/1 Phase 2
Scopolamine Seoul National University Hospital Patients 2016/11/1 Phase 4
Scopolamine Drexel University College of Medicine|Merck Sharp & Dohme Corp.|Drexel University Nausea|Vomiting 2008/4/1
Scopolamine Medical Corps, Israel Defense Force Simulator Sickness 2009/9/1
Scopolamine Xijing Hospital of Digestive Diseases Gastrointestinal Imaging With pCLE 2013/12/1
Scopolamine National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Unipolar Depression|Bipolar Depression 2006/8/1 Phase 2
Scopolamine GlaxoSmithKline Motion Sickness 2016/5/1 Phase 1
Scopolamine University of Iowa|University of Minnesota - Clinical and Translational Science Institute Healthy 2016/11/1 Phase 4
Scopolamine AstraZeneca Memory Impairment|Alzheimer's Disease 2014/1/1 Phase 1
Scopolamine Repurposed Therapeutics, Inc. Motion Sickness 2014/6/1 Phase 2|Phase 3
Scopolamine Takeda Healthy Volunteers 2016/12/5 Phase 1
Scopolamine Pfizer Healthy 2011/4/1 Phase 1
Scopolamine Pfizer Healthy 2011/5/1 Phase 1
Scopolamine Massachusetts General Hospital Major Depressive Disorder 2015/9/1
Scopolamine Shandong University Using Copolamine Butylbromide in Probe-based Confocal Laser Endomicroscopy for Gastroendoscopy Examination 2014/8/1 Phase 1
Scopolamine Tetra Discovery Partners Alzheimer Disease 2017/1/1 Phase 1
Scopolamine Merck Sharp & Dohme Corp. Dementia 2007/6/1 Phase 1
Scopolamine University of California, Los Angeles Social Anxiety Disorder 2013/8/1 Phase 1
Scopolamine Daniela Moga|National Institute on Aging (NIA)|University of Kentucky Alzheimer's Disease|Dementia 2017/4/4 Early Phase 1
Scopolamine National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Mood Disorders|Healthy|Unipolar Depression|Bipolar Depression 2003/2/27
Scopolamine Hebrew Rehabilitation Center, Boston Cholinergic Function 2008/7/1
Scopolamine Mercy Facial Plastic Surgery Center Rhytidoplasty 2013/9/1
Scopolamine Vanderbilt University|University of Washington|Vanderbilt University Medical Center Postoperative Nausea and Vomiting 2016/7/1
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Safety Data of Scopolamine

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
BioBioPha Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60() USA
Chengdu Biopurify Phytochemicals Ltd. China
Chengdu Herbpurify Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60() China
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Related Products

Other Forms of 51-34-3

Name CAS No Formula MW
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26
Scopolamine (butylbromide) 149-64-4 C21H30BrNO4 440.37

Recommended Compounds in mAChR 5-HT Receptor

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
Iloperidone 133454-47-4 C24H27FN2O4 426.48
Tianeptine 72797-41-2 C21H25ClN2O4S 436.95
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
VGX-1027 6501-72-0 C11H11NO3 205.21
Asenapine 65576-45-6 C17H16ClNO 285.77
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
AZD1981 802904-66-1 C19H17ClN2O3S 388.87
4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- 854107-55-4 C22H23ClN2O4S 446.95
Vortioxetine 508233-74-7 C18H22N2S 298.45
Avatrombopag 570406-98-3 C29H34Cl2N6O3S2 649.65
Tasimelteon 609799-22-6 C15H19NO2 245.3169
Rolipram 61413-54-5 C16H21NO3 275.34
RSV604 676128-63-5 C22H17FN4O2 388.39
Cilobradine (hydrochloride) 186097-54-1 C28H39ClN2O5 519.07
Zolpidem 82626-48-0 C19H21N3O 307.39
Vipadenant 442908-10-3 C16H15N7O 321.3366
Curcumin 458-37-7 C21H20O6 368.38
Agomelatine 138112-76-2 C15H17NO2 243.3
Brivaracetam 357336-20-0 C11H20N2O2 212.2887
NSI-189 1270138-40-3 C22H30N4O 366.5
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Route of Synthesis

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References

Protocol Reference

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More Information

Scopolamine

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