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596-51-0 (Glycopyrrolate)

1

Identification

Glycopyrrolate Glycopyrrolate
Name Glycopyrrolate
Formula C19H28BrNO3
MW 398.33
CAS No. 596-51-0
EINECS 209-887-0
Smiles OC(C1=CC=CC=C1)(C(OC(CC2)C[N+]2(C)C)=O)C3CCCC3.[Br-]
Synonyms (1,1-Dimethyl-2,3,4,5-tetrahydropyrrol-3-yl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate bromide; Glycopyrronium bromide; 3-(2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidin-1-ium bromide
InChI InChI=1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
2

Introduction

Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. IC50 Value: Target: mAChR (Muscarinic acetylcholine receptor M1) in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors.

Background Information

Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. ......by AdooQ BioScience, LLC
Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic. ......by BOC Sciences
Glycopyrrolate is a medication of the muscarinic anticholinergic group. It does not cross the blood–brain barrier and consequently has no to few central effects. Glycopyrrolate is a synthetic anticholinergic agent with a quaternary ammonium structure. A muscarinic competitive antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. A synthetic quaternary amine, it is available in oral and intravenous forms. It was developed by Sosei and licensed to Novartis in 2005. ......by MedKoo Biosciences, Inc.
A muscarinic anticholinergic that blocks muscarinic receptors, thus inhibiting cholinergic transmission.COPDApproved ......by ProbeChem
Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. ......by Selleck Chemicals LLC
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013223

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Glycopyrrolate AstraZeneca plc; Pearl Therapeutics Inc Chronic obstructive pulmonary disease 2013/11/30 2015/1/1 Phase 3 Clinical
Glycopyrrolate Merck & Co Inc Anesthesia 2011/12/31 2012/11/30 Phase 3 Clinical
Glycopyrrolate Merck & Co Inc Poison intoxication 2011/10/31 2012/9/30 Phase 3 Clinical
Glycopyrrolate Pearl Therapeutics Inc Chronic obstructive pulmonary disease 2012/4/30 2012/10/1 Phase 2 Clinical
Glycopyrrolate - Launched
7

Safety Data of Glycopyrrolate

Hazard Symbols : Xi
Risk Statements : 36/37/38
Safety Statements : 26
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 10mg/USD60();50mg/USD108() USA
Cayman Chemical Company USA
Changzhou Sanling Chemical Co., Ltd. China
Chengdu Miracle Chemicals Co., Ltd. China
Haikou Hengkangda Chemical Co., Ltd. China
Jai Radhe Sales India
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD108() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD108() China
Sigma-Aldrich, Inc. 5mg/USD67() USA
Spectrum Chemical Mfg. Corp. 1g/USD311() USA
Target Molecule Corp. 10mg/USD38();25mg/USD69();50mg/USD117();100mg/USD198() USA
Tokyo Chemical Industry Co., Ltd. 100mg/USD173() Japan
10

Related Products

Other Forms of 596-51-0

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
Carvedilol 72956-09-3 C24H26N2O4 406.47
PRX-08066 866206-54-4 C19H17ClFN5S 401.89
SCH 527123 473727-83-2 C21H23N3O5 397.42
Vilanterol 503068-34-6 C24H33Cl2NO5 486.43
PH-797804 586379-66-0 C22H19BrF2N2O3 477.3
Umeclidinium (bromide) 869113-09-7 C29H34BrNO2 508.49
Remimazolam 308242-62-8 C21H19BrN4O2 439.3051
Indacaterol 312753-06-3 C24H28N2O3 392.49
Aclidinium (Bromide) 320345-99-1 C26H30BrNO4S2 564.55
Vilanterol (trifenatate) 503070-58-4 C44H49Cl2NO7 774.77
Formoterol 67346-49-0 C19H24N2O4 344.40486
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 666.7
Formoterol (Fumarate) 43229-80-7 C19H24N2O4.1/2C4H4O4<䲧甙Ỵ甚 0.0
Sildenafil 139755-83-2 C22H30N6O4S 474.58
Roflumilast 162401-32-3 C17H14Cl2F2N2O3 403.21
1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea 111406-87-2 C11H12N2O2S 236.29
Alvimopan 156053-89-3 C25H32N2O4 424.53
Tiotropium (Bromide) 136310-93-5 C19H22BrNO4S2 472.42
Remimazolam (benzenesulfonate) 1001415-66-2 C27H25BrN4O5S 597.48
Salmeterol (xinafoate) 94749-08-3 C36H45NO7 603.75
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Route of Synthesis

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References

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More Information

Glycopyrrolate

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