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114-49-8 (Scopolamine (hydrobromide))

1

Identification

Scopolamine (hydrobromide) Scopolamine (hydrobromide)
Name Scopolamine (hydrobromide)
Formula C17H22BrNO4
MW 384.26
CAS No. 114-49-8
EINECS 204-050-6
Smiles CN1[[email protected]@]2([H])[[email protected]](O3)([H])[[email protected]]3([H])[[email protected]]1([H])C[[email protected]](OC([[email protected]](CO)C4=CC=CC=C4)=O)C2.Br
Synonyms Hyoscine hydrobromide; (S)-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 3-hydroxy-2-phenylpropanoate hydrobromide
InChI InChI=1S/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/m1./s1
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Introduction

Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM. Target: mAChR Scopolamine (USAN), also known as levo-duboisine and hyoscine, sold as Scopoderm, is a tropane alkaloid drug with muscarinic antagonist effects.

Background Information

Scopolamine HBr is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 nM. ......by BOC Sciences
Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM. ......by MedChemexpress Co., Ltd.
Scopolamine is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic. ......by MedKoo Biosciences, Inc.
Scopolamine Hydrobromide acts as antimuscarinics like atropine, but may have more central nervous system effects. It is a non-selective muscarinic antagonist. Presently, scopolamine hydrobromide is a widely used clinically to treat motion sickness. ......by MedKoo Biosciences, Inc.
Extracted from Physochlaina infundibularis Kuang dried roots;Store the product in sealed, cool and dry condition ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013148

Storage condition

Solubility

DMSO 77 mg/mL (200 mM); Water 77 mg/mL (200 mM) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 76 mg/mL (197.78 mM); Water76 mg/mL (197.78 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR 5-HT Receptor
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Scopolamine (hydrobromide) - Launched
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Safety Data of Scopolamine (hydrobromide)

Hazard Symbols : Xn
Risk Statements : 22
Safety Statements : 36
RTECS : YM4550000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Alkaloids Corporation India
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 100mg/USD60();500mg/USD144() USA
Cayman Chemical Company USA
Chemada Fine Chemicals Ltd. Israel
Jai Radhe Sales India
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD144() USA
MedKoo Biosciences, Inc. USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD144() China
Target Molecule Corp. 5mg/USD35();20mg/USD88();50mg/USD148();100mg/USD230();200mg/USD382() USA
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Related Products

Other Forms of 114-49-8

Name CAS No Formula MW
Scopolamine (butylbromide) 149-64-4 C21H30BrNO4 440.37
Scopolamine 51-34-3 C17H21NO4 303.35

Recommended Compounds in mAChR 5-HT Receptor

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Scopolamine (hydrobromide)

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