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229975-97-7 (Atazanavir (sulfate))

1

Identification

Atazanavir (sulfate) Atazanavir (sulfate)
Name Atazanavir (sulfate)
Formula C38H54N6O11S
MW 802.93
CAS No. 229975-97-7
EINECS
Smiles O=C(OC)N[[email protected]@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[[email protected]](O)[[email protected]](CC3=CC=CC=C3)NC([[email protected]](C(C)(C)C)NC(OC)=O)=O)=O.O=S(O)(O)=O
Synonyms BMS 232632 sulfate;BMS-232632 sulfate;BMS232632 sulfate;
InChI InChI=1S/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28;1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47);(H2,1,2,3,4)/t29-,30-,31+,32+;/m0./s1
2

Introduction

Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor. Target: HIV-1 protease inhibitor Atazanavir sulfate is a sulfate salt form of atazanavir that is an highly potent HIV-1 protease inhibitor.

Background Information

Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus. ......by BOC Sciences
Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay. ......by Selleck Chemicals LLC
Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient’s lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Cell lines RF/MT-2 strains
Conditions 15 nM; 6 days
Method To determine cytotoxicity, host cells are incubated in the presence of serially diluted Atazanavir for 6 days and cell viability is quantitated using an XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide] assay to calculate the 50% cytotoxic concentrations (CC50s). To assess the effect of human serum proteins on antiviral activity, the 10% fetal calf serum normally used for assays is replaced with 40% adult human serum or 1 mg of α1-acid glycoprotein/mL.
Source Selleck Chemicals LLC

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013070

Storage condition

Solubility

DMSO 104 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 104 mg/mL (129.52 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease Anti-infection
Target HIV Protease HIV
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Atazanavir (sulfate) - Launched
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Safety Data of Atazanavir (sulfate)

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 10mg/USD100(In stock) USA
Abblis Chemicals LLC 5mg/USD110(In stock) USA
Apexbio Technology LLC 5mg/USD70(In stock);50mg/USD350(In stock) USA
Asia Talent Chemical Limited China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD72();50mg/USD144() USA
Carbosynth Limited 10mg/USD63()
Clearsynth Labs Limited 25mg/USD100() India
Matrix Scientific 250mg/USD265() USA
MedChemexpress Co., Ltd. 10mg/USD72();50mg/USD144() USA
Rota Pharm & Chem Co., Ltd. China
Santa Cruz Biotechnology, Inc. 5mg/USD196() USA
Selleck Chemicals LLC 5mg/USD110(In stock);10mg/USD170(In stock);10mM/1mLIn DMSO/USD350(In stock);50mg/USD570(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD72();50mg/USD144() China
Shanghai Julong Pharmaceutical R &amp; D Co., Ltd CHINA
Target Molecule Corp. 10mg/USD96();25mg/USD178();50mg/USD313() USA
Tianjin Chemiway Biopharmer-Tech Co., Ltd. China
Zhejiang Esun Chemical Co., Ltd. China
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Related Products

Other Forms of 229975-97-7

Name CAS No Formula MW
Atazanavir 198904-31-3 C38H52N6O7 704.86
Atazanavir (D18) 1092540-52-7 C38H34D18N6O7 722.97
Atazanavir (D15) 1092540-56-1 C38H37D15N6O7 719.95

Recommended Compounds in HIV Protease HIV

Name CAS No Formula MW
Indinavir (sulfate) 157810-81-6 C36H49N5O8S 711.87
Indinavir 150378-17-9 C36H47N5O4 613.79
Fosamprenavir (Calcium Salt) 226700-81-8 C25H34CaN3O9PS 623.67
Amprenavir 161814-49-9 C25H35N3O6S 505.63
Atazanavir 198904-31-3 C38H52N6O7 704.86
Nelfinavir (Mesylate) 159989-65-8 C33H49N3O7S2 663.89
Darunavir (Ethanolate) 635728-49-3 C29H43N3O8S 593.73
Darunavir 206361-99-1 C27H37N3O7S 547.66
Nelfinavir (Mesylate) 159989-65-8 C33H49N3O7S2 663.8881
Saquinavir 127779-20-8 C38H50N6O5 670.84
Tipranavir 174484-41-4 C31H33F3N2O5S 602.66
Lopinavir 192725-17-0 C37H48N4O5 628.8
Saquinavir (Mesylate) 149845-06-7 C39H54N6O8S 766.95
Ritonavir 155213-67-5 C37H48N6O5S2 720.94
DPC-681 284661-68-3 C35H48FN5O5S 669.85
L-689502 138483-63-3 C39H51N3O7 673.84
Saquinavir (Mesylate) 149845-06-7 C39H54N6O8S 766.9465
Bevirimat 174022-42-5 C36H56O6 584.83
Lamivudine 134678-17-4 C8H11N3O3S 229.26
Didanosine 69655-05-6 C10H12N4O3 236.23

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Atazanavir (sulfate)

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