• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

168626-94-6 (Conivaptan (hydrochloride))

1

Identification

Conivaptan (hydrochloride) Conivaptan (hydrochloride)
Name Conivaptan (hydrochloride)
Formula C32H27ClN4O2
MW 535.04
CAS No. 168626-94-6
EINECS
Smiles O=C(C1=CC=C(NC(C(C=CC=C2)=C2C3=CC=CC=C3)=O)C=C1)N4C5=CC=CC=C5C(NC(C)=N6)=C6CC4.Cl
Synonyms N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride; N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride
InChI InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H
2

Introduction

Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. IC50 value: 0.48 nM (Rat liver V1A receptor); 3.04 nM (Rat kidney V2 receptor) [1] in vitro: YM087 showed high affinity for V1A receptors from rat liver and V2 receptors from rat kidney with Ki values of 0.48 and 3.04 nM, respectively.

Background Information

Conivaptan HCl is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist). ......by BOC Sciences
Conivaptan (hydrochloride) is a non-peptide antagonist of vasopressin receptor, with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. ......by MedChemexpress Co., Ltd.
Conivaptan HCl is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia. ......by Selleck Chemicals LLC
Conivaptan HCl is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012772

Storage condition

Solubility

DMSO 107 mg/ml; Water <1 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 107 mg/mL (199.98 mM); Ethanol7 mg/mL (13.08 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Vasopressin Receptor
Research Area Cardiovascular Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Conivaptan (hydrochloride) - Launched
7

Safety Data of Conivaptan (hydrochloride)

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Abblis Chemicals LLC 50mg/USD240(Out of Stock) USA
AnHui HaiKang Pharmaceutical Co., Ltd. China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD96();50mg/USD288() USA
Carbosynth Limited 100mg/USD84()
Changzhou Hi-tech Chemicals Ltd. China
Chico Pharmaceutical Co., Ltd. (Nanjing) China
Clearsynth Labs Limited 25mg/USD100() India
Matrix Scientific 250mg/USD515() USA
MedChemexpress Co., Ltd. 10mg/USD96();50mg/USD288() USA
Santa Cruz Biotechnology, Inc. 25mg/USD240() USA
Selleck Chemicals LLC 10mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);10mM(in 1mL DMSO)/USD176(in 1mL DMSO);100mg/USD770(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD96();50mg/USD288() China
Target Molecule Corp. 10mg/USD73();100mg/USD237() USA
10

Related Products

Other Forms of 168626-94-6

Name CAS No Formula MW
Conivaptan 210101-16-9 C32H26N4O2 498.57

Recommended Compounds in Vasopressin Receptor

Name CAS No Formula MW
Mozavaptan 137975-06-5 C27H29N3O2 427.5381
Desmopressin 16679-58-6 C46H64N14O12S2 1069.22
Desmopressin (Acetate) 62288-83-9 0.0
Lixivaptan 168079-32-1 C27H21ClFN3O2 473.93
Tolvaptan 150683-30-0 C26H25ClN2O3 448.94
WAY-151932 220460-92-4 C23H19ClN4O 402.88
Terlipressin 14636-12-5 C52H74N16O15S2 1227.37
Desmopressin (Acetate) 62288-83-9 C48H68N14O14S2 1129.26892
Tolvaptan 150683-30-0 C26H25ClN2O3 448.9413

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Conivaptan (hydrochloride)

Tags: buy 168626-94-6 IC50 | 168626-94-6 price | 168626-94-6 cost | 168626-94-6 solubility | 168626-94-6 purchase | 168626-94-6 manufacturer | 168626-94-6 research buy | 168626-94-6 order | 168626-94-6 MSDS | 168626-94-6 chemical structure | 168626-94-6 Storage condition | 168626-94-6 molecular weight | 168626-94-6 mw | 168626-94-6 datasheet | 168626-94-6 supplier | 168626-94-6 cell line | 168626-94-6 NMR | 168626-94-6 MS | 168626-94-6 IR | 168626-94-6 solubility | 168626-94-6 Safe information | 168626-94-6 Qc and Spectral Information | 168626-94-6 Clinical Information | 168626-94-6 Clinical Trial | 168626-94-6 Route of Synthesis | 168626-94-6 storage condition | 168626-94-6 diseases and conditions | 168626-94-6 flash point | 168626-94-6 boiling point | 168626-94-6 melting point | 168626-94-6 storage condition | 168626-94-6 brand