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22254-24-6 (Ipratropium (bromide))

1

Identification

Ipratropium (bromide) Ipratropium (bromide)
Name Ipratropium (bromide)
Formula C20H30BrNO3
MW 412.36
CAS No. 22254-24-6
EINECS 244-873-8
Smiles C[[email protected]@+]1(C(C)C)[[email protected]@](CC[[email protected]@]1([H])C2)([H])C[[email protected]@H]2OC(C(CO)C3=CC=CC=C3)=O.[Br-]
Synonyms [(1R,5S)-8-Methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide; (1R,3r,5S,8s)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
InChI InChI=1S/C20H30NO3.BrH/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H/q+1;/p-1/t16-,17+,18+,19?,21-;
2

Introduction

Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. Target: mAChR Ipratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD).

Background Information

Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. ......by AdooQ BioScience, LLC
Ipratropium bromide, under the trade name Atrovent, structurally similar to atropine, is a muscarinic antagonist and a bronchodilator. ......by BOC Sciences
Ipratropium Bromide is a muscarinic antagonist, bronchodilator. N-Isopropylated atropine. ......by MedKoo Biosciences, Inc.
Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD). ......by Selleck Chemicals LLC
Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD). ......by Target Molecule Corp.
Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012687

Storage condition

Store at +4°C by Tocris Bioscience Inc.

Solubility

DMSO 84 mg/mL; Water 84 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 83 mg/mL (201.27 mM); Water83 mg/mL (201.27 mM); Ethanol83 mg/mL (201.27 mM) by Selleck Chemicals LLC
Soluble to 50 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ipratropium (bromide) - Launched
7

Safety Data of Ipratropium (bromide)

Hazard Symbols : Xn
Risk Statements : 20/22-36
Safety Statements : 26
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD62() USA
MedChemexpress Co., Ltd. 100mg/USD62() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD62() China
Target Molecule Corp. 100mg/USD38() USA
Tocris Bioscience Inc. USA
Zhejiang Dongdong Pharmaceutical Co., Ltd. China
10

Related Products

Other Forms of 22254-24-6

Name CAS No Formula MW
Ipratropium bromide 66985-17-9 C20H32BrNO3 414.38

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Ipratropium (bromide)

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