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66357-59-3 (Ranitidine (hydrochloride))

1

Identification

Ranitidine (hydrochloride) Ranitidine (hydrochloride)
Name Ranitidine (hydrochloride)
Formula C13H23ClN4O3S
MW 350.86
CAS No. 66357-59-3
EINECS 266-333-0
Smiles O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-].[H]Cl
Synonyms N-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitrovinylidenediamine hydrochloride; (E)-N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diamine hydrochloride
InChI InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
2

Introduction

Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production.

Background Information

Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers. ......by AbMole BioScience
Ranitidine is a medication that decreases stomach acid production. It can be used in treatment of peptic ulcer disease. ......by BOC Sciences
Ranitidine hydrochloride is a histamine H2-receptor antagonist used in the treatment of gastrointestinal lesions due to excessive gastric acid secretion. ......by MedKoo Biosciences, Inc.
Ranitidine HCl is a histamine H2-receptor antagonist, inhibiting the normal and meal-stimulated secretion of stomach acid. ......by MedKoo Biosciences, Inc.
Ranitidine is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers. ......by Selleck Chemicals LLC
Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production.Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine. ......by Target Molecule Corp.
Potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012596

Storage condition

Desiccate at +4°C by Tocris Bioscience Inc.

Solubility

DMSO 70 mg/mL; Water 70 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 70 mg/mL (199.5 mM); Water70 mg/mL (199.5 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 50 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Metabolic Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ranitidine (hydrochloride) - Launched
7

Safety Data of Ranitidine (hydrochloride)

Hazard Symbols : F,T
Risk Statements : 20/21/22-39/23/24/25-23/24/25-11
Safety Statements : S22;S24/25
RTECS : KM6557000
WGKGermany : 2
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Apexbio Technology LLC USA
Astatech, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD72();500mg/USD96() USA
Cayman Chemical Company USA
Hainan Zhongxin Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD72();500mg/USD96() USA
MedKoo Biosciences, Inc. USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD72();500mg/USD96() China
Target Molecule Corp. 2mg/USD20();10mg/USD42();50mg/USD96();200mg/USD122() USA
Tocris Bioscience Inc. USA
Zhejiang Ouhua Chemical Imp. & Exp. Co., Ltd. China
10

Related Products

Other Forms of 66357-59-3

Name CAS No Formula MW
Ranitidine 66357-35-5 C13H22N4O3S 314.4

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

Ranitidine (hydrochloride)

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