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2609-46-3 (Amiloride)

1

Identification

Amiloride Amiloride
Name Amiloride
Formula C6H8ClN7O
MW 229.63
CAS No. 2609-46-3
EINECS
Smiles O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
Synonyms MK-870;Midamor;Guanamprazine;Amipramidin; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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Introduction

Amiloride is a potent epithelial sodium channel blocker. Target: Sodium Channel Amiloride is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

Background Information

Amiloride, a pyrazine derivative potassium-sparing diuretic, is a blocker of sodium channel in renal epithelial cells. Amiloride blocked the low threshold Ca2+ current at relatively small concentrations. The effect of amiloride on the T-type channel is do ......by BOC Sciences
Amiloride is a relatively selective inhibitor of the epithelial sodium channel (ENaC), used in the management of hypertension and congestive heart failure. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000012590

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target Sodium Channel
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Amiloride - Launched
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Safety Data of Amiloride

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD66() USA
MedChemexpress Co., Ltd. 100mg/USD66() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD66() China
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Related Products

Other Forms of 2609-46-3

Name CAS No Formula MW
Amiloride (hydrochloride) 2016-88-8 C6H9Cl2N7O 266.09
Amiloride hydrochloride dihydrate 17440-83-4 C6H13Cl2N7O3 302.12

Recommended Compounds in Sodium Channel

Name CAS No Formula MW
Tenapanor 1234423-95-0 C50H66Cl4N8O10S2 1145.05
Eslicarbazepine (acetate) 236395-14-5 C17H16N2O3 296.32
Moricizine 31883-05-3 C22H25N3O4S 427.52
Propafenone (hydrochloride) 34183-22-7 C21H28ClNO3 377.9
Triamterene 396-01-0 C12H11N7 253.26
Ropivacaine (hydrochloride monohydrate) 132112-35-7 C17H29ClN2O2 328.88
Dibucaine (hydrochloride) 61-12-1 C20H30ClN3O2 379.92
Dibucaine 85-79-0 C20H29N3O2 343.46
Amitriptyline (hydrochloride) 549-18-8 C20H24ClN 313.86
Mepivacaine (hydrochloride) 1722-62-9 C15H23ClN2O 282.81
Lamotrigine 84057-84-1 C9H7Cl2N5 256.09
Phenytoin 57-41-0 C15H12N2O2 252.27
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Dyclonine (hydrochloride) 536-43-6 C18H28ClNO2 325.87
Amiloride (hydrochloride) 2016-88-8 C6H9Cl2N7O 266.09
Ranolazine 95635-55-5 C24H33N3O4 427.54
Carbamazepine 298-46-4 C15H12N2O 236.27
Trichlormethiazide 133-67-5 C8H8Cl3N3O4S2 380.66
Riluzole 1744-22-5 C8H5F3N2OS 234.2
Lidocaine 137-58-6 C14H22N2O 234.34

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Amiloride

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