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113-92-8 (Chlorpheniramine (maleate))

1

Identification

Chlorpheniramine (maleate) Chlorpheniramine (maleate)
Name Chlorpheniramine (maleate)
Formula C20H23ClN2O4
MW 390.86
CAS No. 113-92-8
EINECS 204-037-5
Smiles CN(C)CCC(C1=NC=CC=C1)C2=CC=C(Cl)C=C2.OC(/C=CC(O)=O)=O
Synonyms Chlorphenamine hydrogen maleate; 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate; 1-(N,N-Dimethylamino)-3-(p-chlorophenyl)-3-(alpha-pyridyl)propane maleate; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
InChI InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
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Introduction

Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. Target: Histamine H1 Receptor Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM [1].

Background Information

Chlorpheniramine, a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. ......by AbMole BioScience
Chlorpheniramine maleate is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. ......by AdooQ BioScience, LLC
Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. ......by BOC Sciences
Chlorpheniramine maleate is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than Promethazine. Although not generally approved as an antidepressant or anti-anxiety medication, chlorphenamine appears to have these properties as well. In addition to being an histamine H1 receptor antagonist, chlorphenamine has been shown to work as a serotonin-norepinephrine reuptake inhibitor or SNRI. ......by MedKoo Biosciences, Inc.
Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM. ......by Selleck Chemicals LLC
Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist . ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Cell lines MCF-7, MDA-MB 231, and Ehrlich
Conditions Dissolved in water, final concentrations ~500 μM; 48 hours
Method Cells are exposed to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter for the determination of cell growth.
Source Selleck Chemicals LLC

Animal Experiment

Animal Models Male NC/Nga mice, male ICR mice and female BALB/c mice with atopic dermatitis
Dosage 10 mg/kg
Formulation Suspended in 1% (v/v) Tween 80
Administration Orally
Source Selleck Chemicals LLC
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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012589

Storage condition

Solubility

DMSO 80 mg/mL; Water 77 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 78 mg/mL (199.55 mM); Water78 mg/mL (199.55 mM); Ethanol78 mg/mL (199.55 mM); In vivo Saline20 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Chlorpheniramine (maleate) - Launched
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Safety Data of Chlorpheniramine (maleate)

Hazard Symbols : T
Risk Statements : R25
Safety Statements : S36/37/39;S45
Transport Information : UN 2811
RTECS : US6504000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD60();5g/USD96() USA
Cayman Chemical Company USA
Hubei Hengshuo Chemical Co., Ltd. China
Jai Radhe Sales India
LKT Laboratories Inc. USA
MedChemexpress Co., Ltd. 1g/USD60();5g/USD96() USA
MedKoo Biosciences, Inc. USA
SL Drugs and Pharmaceuticals Pvt. Ltd. India
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD96() China
Target Molecule Corp. 2mg/USD20();10mg/USD73();50mg/USD135();200mg/USD265() USA
Zhejiang Wonderful Pharma & Chem Co., Ltd. China
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Related Products

Other Forms of 113-92-8

Name CAS No Formula MW
Chlorpheniramine 132-22-9 C16H19ClN2 274.79

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Chlorpheniramine (maleate)

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